Observational studyBMC gastroenterology2020
Gastroesophageal reflux disease in a typical African population: a symptom-based multicenter study.
Observational study in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Gastro-oesophageal reflux disease symptom subtypes and endoscopy findings: a retrospective, cross-sectional study from Southwestern Nigeria.BMC gastroenterology · 2025Article
- Article
- Understanding the demographic and socioeconomic determinants of morbidity in Eastern Uganda: a retrospective analysis of the Iganga-Mayuge health and demographic surveillance data.BMJ public health · 2024Article
- Clinical features of gastroesophageal reflux disease and erosive esophagitis: Insights from patients undergoing esophagogastroduodenoscopy in resource-limited Ethiopia.World journal of gastroenterology · 2024Article
- Causal association of gastroesophageal reflux disease on irritable bowel syndrome: a two-sample Mendelian randomization study.Frontiers in genetics · 2024Article
- Gastroesophageal reflux disease symptoms and associated factors among university students in Amhara region, Ethiopia, 2021: a cross-sectional study.BMC gastroenterology · 2023Article
- Review
- Correlation between the symptoms of upper gastrointestinal disease and endoscopy findings: Implications for clinical practice.Journal of Taibah University Medical Sciences · 2021Article
- Epidemiological investigation, extraesophageal symptoms and risk factors of gastroesophageal reflux disease in Kashgar, Xinjiang, China.American journal of translational research · 2021Article
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Authors and funding
11 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundThe prevalence of gastroesophageal reflux disease (GERD) in Africa is not known but is believed to be increasing because of demographic and epidemiologic transition. The main objectives of this study were to determine the prevalence and risk factors of GERD, and its degree of overlap with dyspepsia and irritable bowel syndrome (IBS) in Nigeria, a typical African population.
methodsThis was an observational, cross-sectional and descriptive study of adult Nigerians. Diagnosis of GERD was by means of the gastroesophageal reflux disease questionnaire (GERDQ) while the diagnosis of dyspepsia and IBS was based on the Rome III criteria for the diagnosis of functional gastrointestinal disorders. The GERDQ and Rome III questionnaires for dyspepsia and IBS were merged into a composite questionnaire and administered to the study participants who were recruited with a multi-stage sampling technique.
resultsOut of 3520 subjects who participated in the study across the country, 269 (7.6%) satisfied the diagnostic criteria for GERD, while 107 (3.0%) had GERD associated with significant impairment of quality of life. Risk factors of GERD (represented by odds ratios) were age 1.014(95% CI: 1.006-1.022), use of analgesics 1.461 (95% CI: 1.060-2.025), and use of herbs 1.318 (95% CI: 1.020-1.704). Overlap of GERD with dyspepsia and/or IBS was observed in over 50% of cases.
conclusionsThe prevalence of GERD in this study is 7.6%. Age, use of analgesics and use of herbs increase the risk, albeit minimally. A high degree of overlap with dyspepsia and IBS exists in Nigerian patients with GERD.
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