Evidence map›Paper›PMID 32293288›Full record

ArticleBMC gastroenterology2020

Pancreaticoduodenectomy for a primary duodenal capicua transcriptional repressor (CIC) -rearranged sarcoma with severe bleeding: a case report.

Yuichi Aoki, Hisashi Oshiro, Akihiko Yoshida, Kazue Morishima, Atsushi Miki, Hideki Sasanuma, Yasunaru Sakuma, Alan Kawarai Lefor, Naohiro Sata

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yuichi AokiDivision of Gastroenterological, Department of Surgery, General and Transplant Surgery, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan. uand1aoki@gmail.com.
Hisashi OshiroDepartment of Pathology, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan.
Akihiko YoshidaDepartment of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan.
Kazue MorishimaDivision of Gastroenterological, Department of Surgery, General and Transplant Surgery, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan.
Atsushi MikiDivision of Gastroenterological, Department of Surgery, General and Transplant Surgery, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan.
Hideki SasanumaDivision of Gastroenterological, Department of Surgery, General and Transplant Surgery, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan.
Yasunaru SakumaDivision of Gastroenterological, Department of Surgery, General and Transplant Surgery, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan.
Alan Kawarai LeforDivision of Gastroenterological, Department of Surgery, General and Transplant Surgery, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan.
Naohiro SataDivision of Gastroenterological, Department of Surgery, General and Transplant Surgery, Jichi Medical University, 3311-1, Tochigi, Yakushiji Shimotsuke, 329-0498, Japan.
Jichi Medical University · JPTokyo National Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCapicua transcriptional repressor (CIC) -rearranged sarcoma is characterized by small round cells, histologically similar to Ewing sarcoma. However, CIC-rearranged sarcoma has different clinical, histological, and immunohistochemical features from Ewing sarcoma. It is important to differentiate between these tumors. CASE PRESENTATION: The patient is a 44-year-old man with a duodenal tumor diagnosed in another hospital who presented with a history of melena. Laboratory studies showed anemia with a serum hemoglobin of 6.0 g/dL. He was hospitalized and gastrointestinal bleeding was controlled successfully with endoscopy. However, he suffered from appetite loss and vomiting and progression of anemia a few weeks after presentation. Upper gastrointestinal endoscopy showed a circumferential soft tumor in the second portion of the duodenum and the endoscope could not pass distally. Computed tomography scan showed a greater than 10 cm tumor in the duodenum, with compression of the inferior vena cava and infiltrating the ascending colon. A definitive pathologic diagnosis could not be established despite four biopsies from the tumor edge. Due to gastrointestinal obstruction and progression of anemia, a pylorus-preserving pancreaticoduodenectomy with partial resection of the inferior vena cava and right hemicolectomy was performed as a complete tumor resection. The tumor was diagnosed as a CIC-rearranged sarcoma, but 2 months postoperatively local recurrence and distant metastases to the liver and lung were found. The patient died 3 months after surgery.

conclusionsAlthough the only definitive treatment for CIC-rearranged sarcoma is surgical resection, the CIC-rearranged sarcoma is highly malignant with a poor prognosis even after radical resection. More research is needed to establish optimal treatment strategies.

Indexed as

PancreaticoduodenectomyAdultBiomarkers, TumorDiagnosis, DifferentialDuodenal NeoplasmsFatal OutcomeGastrointestinal HemorrhageGene RearrangementHumansMaleRepressor ProteinsSarcomaSarcoma, EwingTranscription FactorsBiomarkers, TumorCIC protein, humanRepressor ProteinsTranscription FactorsCIC-rearranged sarcomaDuodenumEwing-like sarcomaEwing sarcomaGastrointestinal bleedingOncologic emergencyPancreaticoduodenectomy

Identifiers

PMID32293288
PMCPMC7158042
OpenAlexW3015549315

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.