ArticleBMC plant biology2020
Ultrahigh-activity immune inducer from Endophytic Fungi induces tobacco resistance to virus by SA pathway and RNA silencing.
Article in BMC plant biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- Plant immune inducers from fundamental research to applications: Past achievements, current challenges, and future perspectives.Plant communications · 2026Review
- Ubiquitin-Conjugating Enzyme Positively Regulates Salicylic Acid and Jasmonic Acid Biosynthesis to Confer Broad-Spectrum Antiviral Resistance inPlants (Basel, Switzerland) · 2025Article
- A Multi-omics Approach Reveals the Effects of Bio- and Chemical- Pesticides on Rice Yield and Quality under Disease Stress.Rice (New York, N.Y.) · 2025Article
- Alginate oligosaccharides trigger multiple defense responses in tobacco and induce resistance toFrontiers in plant science · 2025Article
- Join the green team: Inducers of plant immunity in the plant disease sustainable control toolbox.Journal of advanced research · 2024Review
- Fungal Endophytes as Mitigators against Biotic and Abiotic Stresses in Crop Plants.Journal of fungi (Basel, Switzerland) · 2024Review
- Plant immune inducer ZNC promotes rutin accumulation and enhances resistance to Botrytis cinerea in tomato.Stress biology · 2023Article
- Mechanisms of Microbial Plant Protection and Control of Plant Viruses.Plants (Basel, Switzerland) · 2022Review
- Metabarcoding and Metabolome Analyses Reveal Mechanisms ofJournal of fungi (Basel, Switzerland) · 2022Article
- Transcriptional and post-transcriptional regulation of RNAi-related gene expression during plant-virus interactions.Stress biology · 2022Review
- Effect of Coated Diammonium Phosphate Combined withACS omega · 2022Article
- The Multifunctions and Future Prospects of Endophytes and Their Metabolites in Plant Disease Management.Microorganisms · 2022Review
- Endophytic extract Zhinengcong alleviates heat stress-induced reproductive defect inFrontiers in plant science · 2022Article
- The Fusaric Acid Derivative qy17 InhibitsFrontiers in microbiology · 2022Article
- Synergistically promoting plant health by harnessing synthetic microbial communities and prebiotics.iScience · 2021Review
- Endophytic Fungi: Biological Control and Induced Resistance to Phytopathogens and Abiotic Stresses.Pathogens (Basel, Switzerland) · 2021Review
- Multigene Phylogeny, Diversity and Antimicrobial Potential of Endophytic Sordariomycetes FromFrontiers in microbiology · 2021Article
- Plant Endophytic Fungus Extract ZNC Improved Potato Immunity, Yield, and Quality.Frontiers in plant science · 2021Article
- A Technical System for the Large-Scale Application of Metabolites FromFrontiers in bioengineering and biotechnology · 2021Article
- High-Throughput Customization of Plant Microbiomes for Sustainable Agriculture.Frontiers in plant science · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPlant viruses cause severe economic losses in agricultural production. An ultrahigh activity plant immune inducer (i.e., ZhiNengCong, ZNC) was extracted from endophytic fungi, and it could promote plant growth and enhance resistance to bacteria. However, the antiviral function has not been studied. Our study aims to evaluate the antiviral molecular mechanisms of ZNC in tobacco.
resultsHere, we used Potato X virus (PVX), wild-type tobacco and NahG transgenic tobacco as materials to study the resistance of ZNC to virus. ZNC exhibited a high activity in enhancing resistance to viruses and showed optimal use concentration at 100-150 ng/mL. ZNC also induced reactive oxygen species accumulation, increased salicylic acid (SA) content by upregulating the expression of phenylalanine ammonia lyase (PAL) gene and activated SA signaling pathway. We generated transcriptome profiles from ZNC-treated seedlings using RNA sequencing. The first GO term in biological process was positive regulation of post-transcriptional gene silencing, and the subsequent results showed that ZNC promoted RNA silencing. ZNC-sprayed wild-type leaves showed decreased infection areas, whereas ZNC failed to induce a protective effect against PVX in NahG leaves.
conclusionAll results indicate that ZNC is an ultrahigh-activity immune inducer, and it could enhance tobacco resistance to PVX at low concentration by positively regulating the RNA silencing via SA pathway. The antiviral mechanism of ZNC was first revealed in this study, and this study provides a new antiviral bioagent.
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