ArticleArthritis & rheumatology (Hoboken, N.J.)2020
On the Alert for Cytokine Storm: Immunopathology in COVID-19.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Arthritis & rheumatology (Hoboken, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 390 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
390citing papers in PubMed, 2 pooled it
15.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tocilizumab: A Therapeutic Cache Against the Treatment of Severe Cases of COVID-19
Assessment of the Influence of Clinical, Functional, Immunological, and Genetic Factors on the Severity of the Course of Coronavirus Infection With SARS-CoV-2 and Post Covid Syndrome
Who cites it
390 citing papers in PubMed, 2 syntheses or guidelines pooled it, 648 citations in OpenAlex.
- Impact of medical therapies for inflammatory bowel disease on the severity of COVID-19: a systematic review and meta-analysis.BMJ open gastroenterology · 2021Pooled it
- Effect of immunosuppression maintenance in solid organ transplant recipients with COVID-19: Systematic review and meta-analysis.Transplant infectious disease : an official journal of the Transplantation Society · 2021Pooled it
- Prediction of Survival by IL-6 in a Randomized Placebo-Controlled Trial of Anakinra in COVID-19 Cytokine Storm.Viruses · 2023Trial
- Randomized, double-blind, controlled trial of human anti-LIGHT monoclonal antibody in COVID-19 acute respiratory distress syndrome.The Journal of clinical investigation · 2022Trial
- Trial
- Multi-antigen coronavirus vaccine induces potent and durable cross-protection against multiple SARS-CoV-2 variants.NPJ vaccines · 2026Article
- Risk of new-onset obstructive sleep apnea up to 4.5 years after COVID-19 in the urban population.Scientific reports · 2026Article
- Efficacy and optimal timing of sivelestat in critically ill patients with COVID-19: a multicenter retrospective cohort study.BMC pulmonary medicine · 2026Article
- Autoantibodies to IL-1Ra and PGRN in severe COVID-19 are associated with inflammation-induced hyperphosphorylated antigen isoforms.Nature communications · 2026Article
- Machine learning, whole genome sequencing, and Mendelian randomization support a role of CRP on COVID-19 severity.Molecular medicine (Cambridge, Mass.) · 2026Article
- Article
- Chemical characterization of Jing Guan Fang and its application in alleviating coronavirus envelope protein-induced proinflammatory responsesJournal of traditional and complementary medicine · 2026Article
- Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- The clinical values of laboratory inflammatory and composite indices in predicting rapidly progressive interstitial lung disease and prognosis in anti-MDA5 dermatomyositis patients.Clinical rheumatology · 2026Article
- Potential predictors of COVID-19 disease infection and severity in Egypt.Scientific reports · 2026Article
- In-hospital cardiovascular outcomes of COVID-19-associated cytokine storm: a population-level study.Frontiers in epidemiology · 2026Article
- Hemophagocytic Lymphohistiocytosis Gene Variants in Severe COVID-19 Cytokine Storm Syndrome.Viruses · 2025Article
- Immune transcriptomic analysis on COVID-19 patients with varying clinical presentations identifies severity markers.Scientific reports · 2025Article
- Incidence and risk factors of new clinical disorders in patients with COVID-19 hyperinflammatory syndrome.Scientific reports · 2025Article
- Neuropilin-1 as a Neuroinflammatory Entry Factor for SARS-CoV-2 Is Attenuated in Vaccinated COVID-19 Patients: A Case-Control Study.Health science reports · 2025Article
330 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
19 authors at 11 institutions in 2 countries.
Lauren A HendersonBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0003-0242-4029
Scott W CannaUPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-3837-5337
Grant S SchulertCincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.ORCID 0000-0001-5923-7051
Stefano VolpiCenter for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.
Pui Y LeeBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Kate F KernanUPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.
Roberto CaricchioTemple University Hospital and Lewis Katz School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0002-1379-1118
Shawn MahmudUniversity of Minnesota Medical Center and University of Minnesota School of Medicine, Minneapolis.
Melissa M HazenBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Olha HalyabarBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Kacie J HoytBoston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Joseph HanIcahn School of Medicine at Mount Sinai, New York, New York.
Alexei A GromCincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.
Marco GattornoCenter for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.
Angelo RavelliClinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.ORCID 0000-0001-9658-0385
Fabrizio De BenedettiOspedale Pediatrico Bambino Gesù, Rome, Italy.ORCID 0000-0001-8749-8232
Edward M BehrensChildren's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.ORCID 0000-0002-4603-7963
Randy Q CronChildren's of Alabama, University of Alabama at Birmingham, Birmingham.ORCID 0000-0003-2661-3086
Peter A NigrovicBoston Children's Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-2126-3702
Boston Children's Hospital · USIstituto Giannina Gaslini · ITCincinnati Children's Hospital Medical Center · USUniversity of Pittsburgh · USBambino Gesù Children's Hospital · ITBrigham and Women's Hospital · USChildren's Hospital of Philadelphia · USChildren's of Alabama · USIcahn School of Medicine at Mount Sinai · USTemple University Hospital · USUniversity of Minnesota Medical Center · US
Funding
Joint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MInflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure RenewalR01GM108618 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOSEPH A CARCILLO · 2014 to 2026
$5.4MLy6 family members in neutrophil biologyR01AR065538 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2014 to 2024
$4.0MBridging the gap between GWAS and mechanism in JIAR01AR073201 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic · 2019 to 2026
$3.2MT resident memory cells in arthritisR01AR075906 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2019 to 2023
$2.1MUnderstanding Interleukin-18 Mediated Susceptibility to Systemic HyperinflammationR01HD098428 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CANNA, SCOTT WILLIAM · 2019 to 2023
$1.7MThe Reprogramming of Regulatory T cells to a Th17 Phenotype in Systemic Juvenile Idiopathic ArthritisK08AR073339 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI HENDERSON, LAUREN A · 2018 to 2022
$840kModulation of neutrophil function through emperipolesisR21AR076630 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2020 to 2021
$545kImpact of emperipolesis on platelet functionR21HL150575 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2020 to 2021
$470kLy6 family members in neutrophil biologyR56AR065538 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI NIGROVIC, PETER A · 2019 to 2019
$411kArbuckle Family Fund for Arthritis ResearchFundación BecharaLupus Research AllianceNational Institute of Child Health and Human Development R01/HD098428NHLBI NIH HHS R21 HL150575NIAMS NIH HHS 2R01/AR065538NIAMS NIH HHS K08 AR073339NIAMS NIH HHS K08/AR073339NIAMS NIH HHS L40 AR065238NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30/AR070253NIAMS NIH HHS R01 AR073201NIAMS NIH HHS R01/AR073201NIAMS NIH HHS R01/AR075906NIAMS NIH HHS R21 AR076630NIAMS NIH HHS R21/AR076630NIAMS NIH HHS R21/HL150575NIAMS NIH HHS R56 AR065538NICHD NIH HHS R01 HD098428NIGMS NIH HHS 2R01/GM108618NIGMS NIH HHS R01 GM108618Rheumatology Research Foundation Investigator AwardRK Mellon Institute for Pediatric ResearchUniversity of Minnesota Medical School Academic Investment Education Program Grant
Abstract
Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19.
Indexed as
Anti-Inflammatory AgentsBetacoronavirusBiomarkersCoronavirus InfectionsCOVID-19Cytokine Release SyndromeEarly Medical InterventionHumansPandemicsPneumonia, ViralSARS-CoV-2Anti-Inflammatory AgentsBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04560205ClinicalTrials.gov
NCT04987853ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.