ArticleThe European journal of neuroscience2020
Phasic cholinergic signaling promotes emergence of local gamma rhythms in excitatory-inhibitory networks.
Article in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Dynamic cholinergic signaling differentially desynchronizes cortical microcircuits dependent on modulation rate and network connectivity.PLoS computational biology · 2026Article
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Review
- Distinct cholinergic circuits underlie discrete effects of reward on attention.Frontiers in molecular neuroscience · 2024Review
- Acetylcholine facilitates localized synaptic potentiation and location specific feature binding.Frontiers in neural circuits · 2023Article
- Vigilance, arousal, and acetylcholine: Optimal control of attention in a simple detection task.PLoS computational biology · 2022Article
- Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.PLoS computational biology · 2022Article
- Disrupted Choline Clearance and Sustained Acetylcholine ReleaseThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- The role of gamma oscillations in central nervous system diseases: Mechanism and treatment.Frontiers in cellular neuroscience · 2022Review
- Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation.PLoS computational biology · 2021Article
- Reduction of falls in a rat model of PD falls by the M1 PAM TAK-071.Psychopharmacology · 2021Article
- The pulse: transient fMRI signal increases in subcortical arousal systems during transitions in attention.NeuroImage · 2021Article
- Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.Movement disorders : official journal of the Movement Disorder Society · 2021Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Recent experimental results have shown that the detection of cues in behavioral attention tasks relies on transient increases of acetylcholine (ACh) release in frontal cortex and cholinergically driven oscillatory activity in the gamma frequency band (Howe et al. Journal of Neuroscience, 2017, 37, 3215). The cue-induced gamma rhythmic activity requires stimulation of M1 muscarinic receptors. Using biophysical computational modeling, we show that a network of excitatory (E) and inhibitory (I) neurons that initially displays asynchronous firing can generate transient gamma oscillatory activity in response to simulated brief pulses of ACh. ACh effects are simulated as transient modulation of the conductance of an M-type K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.