ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020
Sorting nexin 1 loss results in increased oxidative stress and hypertension.
Open access · greenAbstract read
In one paragraph
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Development of a peripheral blood transcriptomic gene signature to predict bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2023Trial
- Role of Renal Dopamine Receptors in the Regulation of Blood Pressure.Biomolecules · 2026Review
- Association of Oxidative Balance Score With All-Cause and Cardiovascular Mortality Among Hypertensive Adults.Reviews in cardiovascular medicine · 2025Article
- Sorting nexins: role in the regulation of blood pressure.The FEBS journal · 2023Review
- New insight into increased angiotensin II type 1 receptor expression in Snx1Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Increased ATHypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Oxidative Stress and Hypertension.Circulation research · 2021Review
- Lipid Rafts and Dopamine Receptor Signaling.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 12 institutions in 3 countries.
Jian YangDepartment of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.
Laureano D AsicoDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Amber L BeitelsheesDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Jun B FeranilDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Xiaoyan WangDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
John E JonesDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Ines ArmandoDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Santiago G CuevasDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Gary L SchwartzDivision of Nephrology and Hypertension, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA.
John G GumsDepartment of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Arlene B ChapmanRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Stephen T TurnerDivision of Nephrology and Hypertension, Department of Internal Medicine, College of Medicine, Mayo Clinic, Rochester, MN, USA.
Eric BoerwinkleHuman Genetics and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA.
Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research, Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Robin A FelderDepartment of Pathology, The University of Virginia School of Medicine, Charlottesville, VA, USA.
Edward J WeinmanDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Chunyu ZengDepartment of Cardiology, Fujian Heart Medical Center, Fujian Medical University Union Hospital, Fujian, P.R.China.
Pedro A JoseDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Van Anthony M VillarDivision of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · USGeorge Washington University · USUniversity of Florida · USArmy Medical University · CNChongqing Medical University · CNEmory University · USMayo Clinic · USMayo Clinic in Arizona · USThe University of Texas Health Science Center at Houston · USUniversity of Florida Health · USUniversity of Virginia · USVeterans Health Administration · US
Funding
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2MSpatiotemporal transregulation of D1-like angiotensin receptors in genetically...P01HL074940 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GILDEA, JOHN JOSEPH · 2004 to 2020
$31.8MRenal Vascular Oxidative Stress in HypertensionP01HL068686 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A., SANDBERG, KATHRYN L · 2001 to 2017
$28.8MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MPharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2005 to 2014
$20.7MUF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2MRENAL DOPAMINE-1 RECEPTOR DEFECT IN HYPERTENSIONR01DK039308 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 1987 to 2020
$7.4MRenal Dopamine Receptor & RegulationR37HL023081 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI JOSE, PEDRO A. · 2007 to 2016
$4.3MGRK4 & Development of Salt SensitivityR01HL092196 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ARMANDO, INES, JOSE, PEDRO A. · 2008 to 2017
$3.6MLipid rafts, dopamine 1 receptor, and hypertensionR01DK119652 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JOSE, PEDRO A. · 2020 to 2023
$2.6MRENAL DOPAMINE RECEPTOR REGULATION AND FUNCTIONR01HL023081 · NHLBI · GEORGETOWN UNIVERSITY · PI JOSE, PEDRO A. · 1985 to 2006
$2.4MRole of Dopamine D2 Receptor in Renal Inflammation and InjuryR01DK090918 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI ARMANDO, INES · 2011 to 2015
$1.7MNCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1 TR000454NHLBI NIH HHS P01 HL068686NHLBI NIH HHS P01 HL074940NHLBI NIH HHS R01 HL023081NHLBI NIH HHS R01 HL092196NHLBI NIH HHS R37 HL023081NIDDK NIH HHS R01 DK039308NIDDK NIH HHS R01 DK090918NIDDK NIH HHS R01 DK119652NIGMS NIH HHS U01 GM074492
Abstract
Acute renal depletion of sorting nexin 1 (SNX1) in mice results in blunted natriuretic response and hypertension due to impaired dopamine D
Indexed as
AnimalsBlood PressureCell LineFemaleHumansHypertensionKidneyKidney Tubules, ProximalMaleMiceNADPH OxidasesOxidation-ReductionOxidative StressProtein TransportReactive Oxygen SpeciesReceptor, Angiotensin, Type 1NADPH OxidasesReactive Oxygen SpeciesReceptor, Angiotensin, Type 1RNA, Small InterferingSNX1 protein, humanSorting Nexinsdopamine D5 receptorhypertensionoxidative stressrenal proximal tubule cellssorting nexin 1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.