ArticleLab on a chip2020
Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics.
Article in Lab on a chip, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.Lab on a chip · 2026Review
- Surface Acoustic Wave Devices: New Mechanisms, Enabling Techniques, and Application Frontiers.Micromachines · 2026Review
- Fluorescence Imaging-Activated Microfluidic Particle Sorting Using Optical Tweezers.Biosensors · 2025Article
- Wireless Frequency-Multiplexed Acoustic Array-based Acoustofluidics.Advanced materials technologies · 2024Article
- Article
- Acoustofluidic Actuation of Living Cells.Micromachines · 2024Review
- Aerosol jet printing of surface acoustic wave microfluidic devices.Microsystems & nanoengineering · 2024Article
- The effect of common paralytic agents used for fluorescence imaging on redox tone and ATP levels in Caenorhabditis elegans.PloS one · 2024Article
- A Comprehensive Review of Surface Acoustic Wave-Enabled Acoustic Droplet Ejection Technology and Its Applications.Micromachines · 2023Review
- Deep Learning for Microfluidic-AssistedMicromachines · 2023Article
- Microfluidic-AssistedCyborg and bionic systems (Washington, D.C.) · 2023Article
- Automatic feedback control by image processing for mixing solutions in a microfluidic device.Biomicrofluidics · 2022Article
- Sonoporation: Past, Present, and Future.Advanced materials technologies · 2022Article
- Potential of the acoustic micromanipulation technologies for biomedical research.Biomicrofluidics · 2021Article
- Amplified piezoelectrically actuated on-chip flow switching for a rapid and stable microfluidic fluorescence activated cell sorter.RSC advances · 2020Article
- Contactless acoustic micro/nano manipulation: a paradigm for next generation applications in life sciences.Proceedings. Mathematical, physical, and engineering sciences · 2020Review
- Acoustic Microfluidic Separation Techniques and Bioapplications: A Review.Micromachines · 2020Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Effectively isolating and categorizing large quantities of Caenorhabditis elegans (C. elegans) based on different phenotypes is important for most worm research, especially genetics. Here we present an integrated acoustofluidic chip capable of identifying worms of interest based on expression of a fluorescent protein in a continuous flow and then separate them accordingly in a high-throughput manner. Utilizing planar fiber optics as the detection unit, our acoustofluidic device requires no temporary immobilization of worms for interrogation/detection, thereby improving the throughput. Implementing surface acoustic waves (SAW) as the sorting unit, our device provides a contact-free method to move worms of interest to the desired outlet, thus ensuring the biocompatibility for our chip. Our device can sort worms of different developmental stages (L3 and L4 stage worms) at high throughput and accuracy. For example, L3 worms can be processed at a throughput of around 70 worms per min with a sample purity over 99%, which remains over 90% when the throughput is increased to around 115 worms per min. In our acoustofluidic chip, the time period to complete the detection and sorting of one worm is only 50 ms, which outperforms nearly all existing microfluidics-based worm sorting devices and may be further reduced to achieve higher throughput.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.