Evidence map›Paper›PMID 32292808›Full record

ArticleMicrobial risk analysis2020

How virus size and attachment parameters affect the temperature sensitivity of virus binding to host cells: Predictions of a thermodynamic model for arboviruses and HIV.

Paul Gale

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial risk analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul GaleIndependent Scientist, 15 Weare Close, Portland, Dorset, DT5 1JP, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus binding to host cells involves specific interactions between viral (glyco)proteins (GP) and host cell surface receptors (Cr) (protein or sialic acid (SA)). The magnitude of the enthalpy of association changes with temperature according to the change in heat capacity (ΔC

Indexed as

AIV, avian influenza virusAntiviralsBBF, brush border fragments from midgutBTV, bluetongue virusCD4, host cell receptor for HIVCp, heat capacity at constant pressureCr, host cell receptorCtotal, number of host cells which can bind virus in a given volume of host fluid (midgut or blood)C.VT, number of host cells with bound virus at temperature TDENV, Dengue virusEA, activation energyEBOV, Zaire ebolavirusEM, electron microscopyEntropyEnv, HIV gp120 trimer envelope protein which binds to a single CD4 moleculeFcT, fraction of arthropod midgut cells with bound virus at temperature TGP, viral (glyco)protein on virus surface that binds to CrHA, haemagglutininHeat capacityHIV, human immunodeficiency virusHSV-2, herpes simplex virus type 2Ka_virus_T, association constant for binding of virus to host cells at temperature TKd_receptor_T, dissociation constant for GP from Cr at temperature TKd_virus, dissociation constant for virus from host cellM, molar (moles dm-3)n, number of GP/Cr contacts made on virus binding to cellpcompleteT, probability given a virion has bound to the surface of a midgut cell that that midgut cell becomes infected and that its progeny viruses go on to infect the salivary gland so completing the arthropod infection process within the life time of the arthropod at temperature TptransmissionT, probability of successful infection of the arthropod salivary glands after oral exposure at temperature TR, ideal gas constantSA, sialic acidSIV, simian immunodeficiency virusTemperatureVfree, virus not bound to cellsVirus sizeVtotal, virus challenge dose in volume of host fluidWEEV, Western equine encephalitis virusWNV, West Nile virusZnOT, zinc oxide tetrapodΔCp, change in heat capacityΔGa_virus_T, change in Gibbs free energy on association of virus and host cell at temperature TΔHa_receptor_T, change in enthalpy for binding of virus GP to host Cr receptor at a temperature TΔHa_virus_T, change in enthalpy for binding of virus to host cell at temperature TΔSa_immob, change in entropy on immobilization of whole virus to cell surfaceΔSa_non_specific, change in entropy on immobilization of virus to cell surface through non-specific bindingΔSa_receptor_T, change in entropy for binding of virus GP to host Cr receptorΔSa_specific, change in entropy on immobilization of virus to cell surface through specific GP/Cr-driven bindingΔSa_virus_T, change in entropy for binding of virus to host cell at temperature T

Identifiers

PMID32292808
PMCPMC7110232
OpenAlexW3011790364

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.