ArticleToxicology reports2020
Gestational and lactational exposition to di-
Article in Toxicology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Phthalates exposure and attention-deficit/hyperactivity disorder in children: a systematic review of epidemiological literature.Environmental science and pollution research international · 2020Pooled it
- Phthalates Induced Neurotoxicity: A Mechanistic Approach.Central nervous system agents in medicinal chemistry · 2026Review
- Exposure to Microplastics during Early Developmental Stage: Review of Current Evidence.Toxics · 2022Review
- Effect of phthalates exposure during perinatal period on hormonal profile in Mexican males during their first months of life.Toxicology reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Di-n-butyl phthalate (DBP) cause significant deficits in cognition and memory, however the neuroanatomical basis for impairments remain poorly understood. This study evaluates neurobehavioral changes in rats for three successive generations between non-siblings by administering DBP at 500mg/kg bw dose through oral gavage from gestation day-6 to 21 and lactation (3-weeks). Weaning period evaluations and developmental deficits assessed showed variations specific to generation and the toxic potential of DBP was confounded by behavioral deficits that include changes in sensorimotor development reflex response, poor performance, low memory retention and greater latency period. The cytoarchitectural alterations witnessed in hippocampus include condensed nuclei, vacuole formation and remarkable degeneration, shrinkage of pyramidal neurons in CA1 and CA3 regions; disorganized hilar cells and hyperplasia in dentate gyrus. Comparatively, the enlisted changes were high in subsequent generations than preceding and correlates assessed between cognitive impairment(s) and endocrine function confirm a link indicating vulnerability of immature animals as target to disrupt neural and endocrine functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.