Evidence map›Paper›PMID 32292507›Full record

ArticleTheranostics2020

PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury.

Zhengze Xue, Yu Zhang, Yuanxing Liu, Cheng Zhang, Xiu-da Shen, Feng Gao, Ronald W Busuttil, Shusen Zheng, Jerzy W Kupiec-Weglinski, Haofeng Ji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zhengze XueDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
Yu ZhangDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
Yuanxing LiuDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
Cheng ZhangDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
Xiu-da ShenDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.
Feng GaoDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.
Ronald W BusuttilDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.
Shusen ZhengDepartment of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.
Jerzy W Kupiec-WeglinskiDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.
Haofeng JiDumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA, USA.
University of California, Los Angeles · USFirst Affiliated Hospital Zhejiang University · CNZhejiang University · CN

Funding

Regulation of Innate Immune Responses by Alloimmunity in Liver Ischemia-Reperfusion InjuryP01AI120944 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Fady M Kaldas · 2017 to 2026
$20.0M
NRF2 - SIRT1 SIGNALING AXIS IN LIVER TRANSPLANT REJUVENATIONR01DK062357 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUPIEC-WEGLINSKI, JERZY W · 2003 to 2025
$8.4M
Tim Costimulation in Liver Transplant Ischemia InjuryR01DK102110 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUPIEC-WEGLINSKI, JERZY W · 2015 to 2019
$1.7M
TIM-3 Negative Costimulation Signaling at the Innate-Adaptive Immune interface in Liver Transplant Ischemia-Reperfusion InjuryR01DK107533 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUPIEC-WEGLINSKI, JERZY W · 2016 to 2020
$1.7M
Ischemia / Reperfusion Injury Mediated TIM-3+CD4+ T Cell Exhaustion In Liver TransplantR21AI138165 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JI, HAOFENG · 2018 to 2019
$428k
PACAP Mediated Neural Regulation of Hepatic Inflammation in Orthotopic Liver TransplantationR21AI122155 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JI, HAOFENG · 2016 to 2017
$424k
NIAID NIH HHS P01 AI120944NIAID NIH HHS R21 AI122155NIAID NIH HHS R21 AI138165NIDDK NIH HHS R01 DK062357NIDDK NIH HHS R01 DK102110NIDDK NIH HHS R01 DK107533
6 · The paper itself

Abstract

Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an unresolved problem in clinical orthotopic liver transplantation (OLT). Autophagy, an intracellular self-digesting progress, is responsible for cell reprograming required to regain post-stress homeostasis.

Indexed as

Reperfusion InjuryAnimalsAutophagyCyclic AMP Response Element-Binding ProteinHepatocytesKruppel-Like Factor 4Kruppel-Like Transcription FactorsLiverLiver TransplantationMaleMiceMice, Inbred C57BLPituitary Adenylate Cyclase-Activating PolypeptidePrimary Graft DysfunctionSpecimen HandlingCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinKlf4 protein, mouseKruppel-Like Factor 4Kruppel-Like Transcription FactorsPituitary Adenylate Cyclase-Activating PolypeptideCREBLiver Ischemia Reperfusion Injury, Orthotopic Liver Transplantation, PACAP, KLF4

Identifiers

PMID32292507
PMCPMC7150481
OpenAlexW3015221583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.