Evidence map›Paper›PMID 32292505›Full record

ArticleTheranostics2020

The WW domains dictate isoform-specific regulation of YAP1 stability and pancreatic cancer cell malignancy.

Qiang Guo, Meiyu Quan, Jinglai Dong, Jing Bai, Jie Wang, Rui Han, Wei Wang, Yaxin Cai, Yu-Qing Lv, Qianjie Chen and 9 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate.International journal of molecular sciences · 2024
    Review
  7. Targeting Neuraminidase 4 Attenuates Kidney Fibrosis in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. An FGFR/AKT/SOX2 Signaling Axis Controls Pancreatic Cancer Stemness.Frontiers in cell and developmental biology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Qiang GuoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Meiyu QuanSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jinglai DongCenter for Precision Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Jing BaiSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jie WangSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Rui HanSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wei WangCenter for Precision Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Yaxin CaiCenter for Precision Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Yu-Qing LvCenter for Precision Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Qianjie ChenSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Huijing XuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Han-Deng LyuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Liancheng DengCenter for Precision Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.
Depu ZhouSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Xueyuan XiaoKey Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Beijing Normal University, Beijing 100875, China.
Stijn De LangheDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, 35294-2182 AL, USA.
Daniel D BilladeauDivision of Oncology Research, and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
Zhenkun LouDivision of Oncology Research, and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.
Jin-San ZhangSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wenzhou Medical University · CN

Funding

HL-Lung stem cells and their niches.R01HL132156 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LANGHE, STIJN PIET JOHAN · 2016 to 2019
$2.0M
HL-Role of c-Myc in myofibroblast differentiation in pulmonary fibrosisR01HL126732 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LANGHE, STIJN PIET JOHAN, RICHES, DAVID W. · 2015 to 2018
$1.8M
Epithelial stem cell hippo signaling in pulmonary fibrosisR01HL146461 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DE LANGHE, STIJN PIET JOHAN · 2019 to 2021
$1.6M
NHLBI NIH HHS R01 HL126732NHLBI NIH HHS R01 HL132156NHLBI NIH HHS R01 HL146461
6 · The paper itself

Abstract

YAP1 is a key mediator of the Hippo pathway capable of exerting a profound effect on organ size as well as tumorigenesis. Alternative mRNA splicing of human YAP1 results in at least 8 protein isoforms that differ within the 2

Indexed as

Adaptor Proteins, Signal TransducingTranscription FactorsAdenocarcinomaAnimalsCarcinogenesisCell Line, TumorCell Transformation, NeoplasticGene Expression Regulation, NeoplasticHEK293 CellsHumansMaleMiceMice, Inbred BALB CMice, NudeNeoplasm InvasivenessPancreatic NeoplasmsAdaptor Proteins, Signal TransducingProtein IsoformsRNA, MessengerTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsisoformLATS1pancreatic cancerprotein stabilityWW domainYAP1

Identifiers

PMID32292505
PMCPMC7150473
OpenAlexW3016060523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.