Evidence map›Paper›PMID 32292488›Full record

ArticleNano today2019

Designing inorganic nanomaterials for vaccines and immunotherapies.

Krystina L Hess, Igor L Medintz, Christopher M Jewell

Abstract read
In one paragraph

Article in Nano today, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  5. Review
  6. Application of nanomedicines in tumor immunotherapy.Journal of molecular cell biology · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Nanoimmunotherapy: the smart trooper for cancer therapy.Exploration of targeted anti-tumor therapy · 2025
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Krystina L HessFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive, College Park, MD, 20742, USA.
Igor L MedintzCenter for Bio/Molecular Science and Engineering Code 6900, U.S. Naval Research Laboratory, 4555 Overlook Ave SW, Washington, DC, 20375, USA.
Christopher M JewellFischell Department of Bioengineering, University of Maryland, 8278 Paint Branch Drive, College Park, MD, 20742, USA.

Funding

Programming immune function through modular assembly of polyionic immune signalsR01EB027143 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI JEWELL, CHRISTOPHER M · 2019 to 2022
$1.6M
Harnessing biomaterials to study the link between local lymph node function and systemic toleranceR01EB026896 · NIBIB · UNIV OF MARYLAND, COLLEGE PARK · PI JEWELL, CHRISTOPHER M · 2018 to 2021
$1.5M
Tunable Assembly of Regulatory Immune Signals to Promote Myelin-specific ToleranceI01BX003690 · VA · BALTIMORE VA MEDICAL CENTER · PI Christopher M Jewell · 2017 to 2026
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BLRD VA I01 BX003690NIBIB NIH HHS R01 EB026896NIBIB NIH HHS R01 EB027143
6 · The paper itself

Abstract

Vaccines and immunotherapies have changed the face of health care. Biomaterials offer the ability to improve upon these medical technologies through increased control of the types and concentrations of immune signals delivered. Further, these carriers enable targeting, stability, and delivery of poorly soluble cargos. Inorganic nanomaterials possess unique optical, electric, and magnetic properties, as well as defined chemistry, high surface-to-volume- ratio, and high avidity display that make this class of materials particularly advantageous for vaccine design, cancer immunotherapy, and autoimmune treatments. In this review we focus on this understudied area by highlighting recent work with inorganic materials - including gold nanoparticles, carbon nanotubes, and quantum dots. We discuss the intrinsic features of these materials that impact the interactions with immune cells and tissue, as well as recent reports using inorganic materials across a range of emerging immunological applications.

Indexed as

carbon nanotubegold nanoparticleimmunologynanomaterialquantum dotvaccine and immunotherapy

Identifiers

PMID32292488
PMCPMC7156029

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.