Evidence map›Paper›PMID 32292481›Full record

ArticleAdvances in hematology2020

Thrombophilic Risk of Factor V Leiden, Prothrombin G20210A, MTHFR, and Calreticulin Mutations in Essential Thrombocythemia Egyptian Patients.

Mohamed S El-Ghonemy, Solafa El Sharawy, Maryan Waheeb Fahmi, Shaimaa El-Ashwah, May Denewer, M A El-Baiomy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mohamed S El-GhonemyHematology Unit, Clinical Pathology Department, Mansoura University Faculty of Medicine, Mansoura, Egypt.ORCID https://orcid.org/0000-0003-1192-7162
Solafa El SharawyHematology Unit, Clinical Pathology Department, Mansoura University Faculty of Medicine, Mansoura, Egypt.
Maryan Waheeb FahmiMedical Oncology Unit, Oncology Center, Mansoura University, Faculty of Medicine, Mansoura, Egypt.
Shaimaa El-AshwahClinical Hematology Unit, Oncology Center, Mansoura University, Faculty of Medicine, Mansoura, Egypt.
May DenewerClinical Hematology Unit, Oncology Center, Mansoura University, Faculty of Medicine, Mansoura, Egypt.
M A El-BaiomyMedical Oncology Unit, Oncology Center, Mansoura University, Faculty of Medicine, Mansoura, Egypt.ORCID https://orcid.org/0000-0001-8702-7633
Mansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEssential thrombocythemia (ET) is one of the myeloproliferative neoplasms characterized by a sustained elevation of platelet numbers with a tendency for thrombosis and hemorrhage. The aim of this work is to establish the relation between calreticulin, factor V Leiden, prothrombin G20210A, and MTHFR mutations in ET patients and the thrombotic risk of these patients.

methodsThis study was carried out on 120 ET patients and 40 apparently healthy individuals as a control group.

resultsThere were increases in WBCs, PLT counts, PT, fibrinogen concentration factor V Leiden, and MTHFR mutation in ET patients as compared to the control group (

conclusionThere is a significant increase risk of thrombosis in ET patients with CALR mutation, thrombophilic mutations, as well as factor V Leiden and prothrombin gene mutation with a risk of developing leukemic transformation.

Identifiers

PMID32292481
PMCPMC7149341
OpenAlexW3013462638

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.