Evidence map›Paper›PMID 32292480›Full record

ArticleInternational journal of analytical chemistry2020

Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application.

Shuang-Long Li, Yong-Liang Zhu, Yi Zhang, Shu-Han Liu, Xiang-Die Wang, Xiang-Jun Qiu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shuang-Long LiMedical College of Henan University of Science and Technology, Luoyang 471023, China.ORCID https://orcid.org/0000-0002-6099-9894
Yong-Liang ZhuMedical College of Henan University of Science and Technology, Luoyang 471023, China.
Yi ZhangMedical College of Henan University of Science and Technology, Luoyang 471023, China.
Shu-Han LiuMedical College of Henan University of Science and Technology, Luoyang 471023, China.
Xiang-Die WangMedical College of Henan University of Science and Technology, Luoyang 471023, China.
Xiang-Jun QiuMedical College of Henan University of Science and Technology, Luoyang 471023, China.ORCID https://orcid.org/0000-0002-7644-9598
Henan University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our research, a straightforward UPLC-MS/MS method, with diazepam as the internal standard (IS), was proposed and acknowledged to determine the concentrations of enasidenib in rat plasma. When preparing the sample, we used acetonitrile for protein precipitation. The gradient elution method was used, and the mobile phase was acetonitrile and 0.1% formic acid. Diazepam was used as the IS. We used the Acquity UPLC BEH C18 column to separate enasidenib and IS. Under the positive ion electrospray ionization (ESI) source conditions, the mass transfer pairs of enasidenib were monitored by multiple reaction monitoring (MRM) to be

Identifiers

PMID32292480
PMCPMC7150726
OpenAlexW3014491090

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.