Evidence map›Paper›PMID 32292420›Full record

ReviewFrontiers in genetics2020

Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in

Tatiana Shaurova, Letian Zhang, David W Goodrich, Pamela A Hershberger

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 84 citations in OpenAlex.

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  19. EHMT2-mediated transcriptional reprogramming drives neuroendocrine transformation in non-small cell lung cancer.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tatiana ShaurovaDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Letian ZhangDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
David W GoodrichDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Pamela A HershbergerDepartment of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States.
Roswell Park Comprehensive Cancer Center · US

Funding

NOTCH signaling controls transformation to androgen independent neuroendocrine prostate cancerR01CA234162 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI GOODRICH, DAVID W. · 2019 to 2024
$3.0M
Exploiting RB1 deficiency for the treatment of lethal neuroendocrine prostate cancerR01CA207757 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI ELLIS, LEIGH, GOODRICH, DAVID W. · 2016 to 2020
$2.8M
Precision vitamin D supplementation as a novel approach to prevent lung cancer progressionR03CA249411 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI HERSHBERGER, PAMELA A · 2020 to 2021
$175k
NCI NIH HHS R01 CA207757NCI NIH HHS R01 CA234162NCI NIH HHS R03 CA249411
6 · The paper itself

Abstract

Somatic alterations in the epidermal growth factor receptor gene (

Indexed as

acquired resistanceEGFR mutant lung cancerEGFR tyrosine kinase inhibitorsepithelial-mesenchymal transitionlineage plasticityneuroendocrine transformationRb1

Identifiers

PMID32292420
PMCPMC7121227
OpenAlexW3013493241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.