ArticleFrontiers in neurology2020
Ripples Have Distinct Spectral Properties and Phase-Amplitude Coupling With Slow Waves, but Indistinct Unit Firing, in Human Epileptogenic Hippocampus.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Common Data Elements for Preclinical High-Frequency Oscillations in Epilepsy.Epilepsy currents · 2026Review
- Epileptogenicity alters intrahippocampal ripple propagation.medRxiv : the preprint server for health sciences · 2026Article
- Noninvasive classification of physiological and pathological high frequency oscillations in children.Brain communications · 2025Article
- Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples.Brain communications · 2025Article
- Multivariate sharp-wave ripples in schizophrenia during awake state.Psychiatry and clinical neurosciences · 2024Article
- Pathological and Physiological High-frequency Oscillations on Electroencephalography in Patients with Epilepsy.Neuroscience bulletin · 2024Review
- Ripple-locked coactivity of stimulus-specific neurons and human associative memory.Nature neuroscience · 2024Article
- Neural oscillatory characteristics of feedback-associated activity in globus pallidus interna.Scientific reports · 2023Article
- Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy.Neurobiology of disease · 2022Article
- A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations.Nature communications · 2022Review
- Drug-resistant epilepsy and the hypothesis of intrinsic severity: What about the high-frequency oscillations?Epilepsia open · 2022Review
- Mesial-Temporal Epileptic Ripples Correlate With Verbal Memory Impairment.Frontiers in neurology · 2022Article
- Accuracy of high-frequency oscillations recorded intraoperatively for classification of epileptogenic regions.Scientific reports · 2021Article
- Are HFOs in the Intra-operative ECoG Related to Hippocampal Sclerosis, Volume and IQ?Frontiers in neurology · 2021Article
- Epileptic High-Frequency Oscillations in Intracranial EEG Are Not Confounded by Cognitive Tasks.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
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Abstract
Ripple oscillations (80-200 Hz) in the normal hippocampus are involved in memory consolidation during rest and sleep. In the epileptic brain, increased ripple and fast ripple (200-600 Hz) rates serve as a biomarker of epileptogenic brain. We report that both ripples and fast ripples exhibit a preferred phase angle of coupling with the trough-peak (or On-Off) state transition of the sleep slow wave in the hippocampal seizure onset zone (SOZ). Ripples on slow waves in the hippocampal SOZ also had a lower power, greater spectral frequency, and shorter duration than those in the non-SOZ. Slow waves in the mesial temporal lobe modulated the baseline firing rate of excitatory neurons, but did not significantly influence the increased firing rate associated with ripples. In summary, pathological ripples and fast ripples occur preferentially during the On-Off state transition of the slow wave in the epileptogenic hippocampus, and ripples do not require the increased recruitment of excitatory neurons.
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