Evidence map›Paper›PMID 32292220›Full record

ArticleTrends in analytical chemistry : TRAC2019

Analysis of circulating non-coding RNAs in a non-invasive and cost-effective manner.

Yu-Min Wang, Michael Patrick Trinh, Yongzan Zheng, Kaizhu Guo, Luis A Jimenez, Wenwan Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in analytical chemistry : TRAC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  18. Epigenetic Landscape of Liquid Biopsy in Colorectal Cancer.Frontiers in cell and developmental biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu-Min WangDepartment of Chemistry, University of California at Riverside, Riverside, California 92521, United States.
Michael Patrick TrinhDepartment of Chemistry, University of California at Riverside, Riverside, California 92521, United States.
Yongzan ZhengDepartment of Chemistry, University of California at Riverside, Riverside, California 92521, United States.
Kaizhu GuoDepartment of Chemistry, University of California at Riverside, Riverside, California 92521, United States.
Luis A JimenezProgram in Biomedical Sciences, University of California at Riverside, Riverside, California 92521, United States.
Wenwan ZhongDepartment of Chemistry, University of California at Riverside, Riverside, California 92521, United States.

Funding

3-Dimensional profile of circulating miRNA for early cancer detectionR01CA188991 · NCI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ZHONG, WENWAN · 2015 to 2018
$1.3M
NCI NIH HHS R01 CA188991
6 · The paper itself

Abstract

Non-coding RNAs (ncRNAs) participate in regulation of gene expression, and are highly relevant to pathological development. They are found to be stably present in diverse body fluids, including those in the circulatory system, which can be sampled non-invasively for clinical tests. Thus, circulating ncRNAs have great potential to be disease biomarkers. However, tremendous efforts are desired to discover and utilize ncRNAs as biomarkers in clinical diagnosis, calling for technological advancement in analysis of circulating ncRNAs in biospecimens. Hence, this review summarizes the recent developments in this area, highlighting the works devoted to cancer diagnosis and prognosis. Three main directions are focused: 1) Extraction and purification of ncRNAs from body fluids; 2) Quantification of the purified circulating ncRNAs; and 3) Microfluidic platforms for integration of both steps to enable point-of-care diagnostics. These technologies have laid a solid foundation to move forward the applications of circulating ncRNAs in disease diagnosis and cure.

Indexed as

DetectionDisease biomarkerExtractionLiquid biopsyNon-coding RNAPoint-of-care diagnosticsPurificationQuantification

Identifiers

PMID32292220
PMCPMC7156030

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.