Evidence map›Paper›PMID 32291901›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020

A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank.

Esther S Oh, Oluwaseun Akeju, Michael S Avidan, Colm Cunningham, Kathleen M Hayden, Richard N Jones, Ara S Khachaturian, Babar A Khan, Edward R Marcantonio, Dale M Needham and 7 more

Registry-linked trialAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04713644 (Study of the Association Between Burst Suppression During Anesthetic Induction With Propofol in Cardiac Surgery in Patients Over 65 Years of Age With Postoperative Delirium), which is not on this map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04713644 completednot on this mapstarted 2021, after this paper: background citation

Study of the Association Between Burst Suppression During Anesthetic Induction With Propofol in Cardiac Surgery in Patients Over 65 Years of Age With Postoperative Delirium

TypeobservationalSponsorPontificia Universidad Catolica de ChileRan2021 to 2024Enrolled78ConditionsPostoperative DeliriumArmsStandardized Propofol Administration
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021
    Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Catalyzing delirium research: The NIDUS delirium network.Journal of the American Geriatrics Society · 2024
    Article
  13. Advancing specificity in delirium: The delirium subtyping initiative.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  14. Article
  15. Review
  16. Review
  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Esther S OhDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Oluwaseun AkejuDepartment of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Michael S AvidanDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Colm CunninghamSchool of Biochemistry and Immunology & Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Richard N JonesDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Ara S KhachaturianCampaign to Prevent Alzheimer's Disease, Rockville, Maryland, USA.
Babar A KhanDivision of Pulmonary,  Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Edward R MarcantonioDivision of General Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Dale M NeedhamDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Karin J NeufeldDepartment of Psychiatry and Behavioral Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Louise RoseFlorence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.
Jessica SpenceDepartments of Anesthesiology and Critical Care, McMaster University, Hamilton, Ontario, Canada.
Zoë TiegesEdinburgh Delirium Research Group, University of Edinburgh, Edinburgh, Scotland, UK.
Phillip VlisidesDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Sharon K InouyeMarcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, Massachusetts, USA.
NIDUS Writing Group

Funding

NIDUS III: Advanced-Stage Development and Utilization of the NIDUS Research Infrastructure to Advance Interdisciplinary Aging Research inDeliriumR33AG071744 · NIA · JOHNS HOPKINS UNIVERSITY · PI John W. Devlin, Esther Seunghee Oh · 2021 to 2026
$4.7M
Supplement to Network for Investigation of Delirium across the U.S (NIDUS)R24AG054259 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2016 to 2020
$4.3M
NIA NIH HHS R24 AG054259NIA NIH HHS R33 AG071744
6 · The paper itself

Abstract

Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting that intervening on delirium may represent an important opportunity for delaying the onset or progression of dementia. To accelerate the current understanding of delirium, the Network for Investigation of Delirium: Unifying Scientists (NIDUS) held a conference "Advancing Delirium Research: A Scientific Think Tank" in June 2019. This White Paper encompasses the major knowledge and research gaps identified at the conference: advancing delirium definition and measurement, understanding delirium pathophysiology, and prevention and treatment of delirium. A roadmap of research priorities is proposed to advance the field in a systematic, interdisciplinary, and coordinated fashion. A call is made for an international consortium and biobank targeted to delirium, as well as a public health campaign to advance the field.

Indexed as

Biomedical ResearchCognitionDeliriumAgedAttentionDementiaHumansPublic Healthbiomarkersdefinitiondeliriumdementiadiagnosismeasurementpathophysiologypreventionpublic health campaigntreatment

Identifiers

PMID32291901
PMCPMC7317361

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.