Evidence map›Paper›PMID 32291793›Full record

ReviewJournal of fish diseases2020

Review of diseases and health management in zebrafish Danio rerio (Hamilton 1822) in research facilities.

M L Kent, J L Sanders, S Spagnoli, C E Al-Samarrie, K N Murray

Open access · greenAbstract readReview
In one paragraph

Review in Journal of fish diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. bioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Current research in parasitology & vector-borne diseases · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Application of an eDNA assay for the detection ofAquaculture (Amsterdam, Netherlands) · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Biliary Atresia Animal Models: Is the Needle in a Haystack?International journal of molecular sciences · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Recent Advances with Fish Microsporidia.Experientia supplementum (2012) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

M L KentDepartment of Microbiology, Oregon State University, Corvallis, Oregon.ORCID https://orcid.org/0000-0001-7968-5142
J L SandersDepartment of Biomedical Sciences, Oregon State University, Corvallis, Oregon.
S SpagnoliDepartment of Biomedical Sciences, Oregon State University, Corvallis, Oregon.
C E Al-SamarrieDepartment of Microbiology, Oregon State University, Corvallis, Oregon.ORCID https://orcid.org/0000-0002-4272-3771
K N MurrayZebrafish International Resource Center, Eugene, Oregon.
Oregon State University · US

Funding

Zebrafish International Resource Center (ZIRC)P40OD011021 · OD · UNIVERSITY OF OREGON · PI Zoltan Marton Varga · 2012 to 2026
$36.0M
Control of Diseases in Zebrafish Research FacilitiesR24OD010998 · OD · OREGON STATE UNIVERSITY · PI KENT, MICHAEL LAWRENCE · 2012 to 2021
$3.0M
SCREENING BIOLOGICAL MATERIAL FOR ACTIVITY AGAINST TROPICAL DISEASE AGENTSU01TW001021 · FIC · SMITHSONIAN INSTITUTION · PI RAMIREZ, MANUEL · 1998 to 2002
$2.1M
An accessible, scalable, patient-facing mHealth application for self-care of heart failure in LMICR21TW010998 · FIC · YALE UNIVERSITY · PI SCHWARTZ, JEREMY IAN, SSINABULYA, ISAAC · 2019 to 2020
$365k
NIH HHS P40 OD011021NIH HHS R24 OD010998NIH Office of Research Infrastructure Programs P40OD01 1021NIH Office of Research Infrastructure Programs R24OD010998
6 · The paper itself

Abstract

The use of zebrafish (Danio rerio) in biomedical research has expanded at a tremendous rate over the last two decades. Along with increases in laboratories using this model, we are discovering new and important diseases. We review here the important pathogens and diseases based on some 20 years of research and findings from our diagnostic service at the NIH-funded Zebrafish International Resource Center. Descriptions of the present status of biosecurity programmes and diagnostic and treatment approaches are included. The most common and important diseases and pathogens are two parasites, Pseudoloma neurophilia and Pseudocapillaria tomentosa, and mycobacteriosis caused by Mycobacterium chelonae, M. marinum and M. haemophilum. Less common but deadly diseases are caused by Edwardsiella ictaluri and infectious spleen and kidney necrosis virus (ISKNV). Hepatic megalocytosis and egg-associated inflammation and fibroplasia are common, apparently non-infectious, in zebrafish laboratories. Water quality diseases include supersaturation and nephrocalcinosis. Common neoplasms are spindle cell sarcomas, ultimobranchial tumours, spermatocytic seminomas and a small-cell carcinoma that is caused by a transmissible agent. Despite the clear biosecurity risk, researchers continue to use fish from pet stores, and here, we document two novel coccidia associated with significant lesions in zebrafish from one of these stores.

Indexed as

Fish DiseasesZebrafishAnimalsAnimals, LaboratoryCommunicable Disease ControlOregonResearchbiosecurityDanio reriodiagnosticsfish diseasestreatment

Identifiers

PMID32291793
PMCPMC7253333
OpenAlexW3016097937

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.