Evidence map›Paper›PMID 32291620›Full record

Trial reportDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2020

Efficacy of furosemide-albumin compared with furosemide in critically ill hypoalbuminemia patients admitted to intensive care unit: a prospective randomized clinical trial.

Ata Mahmoodpoor, Sahra Zahedi, Arezou Pourakbar, Hamed Hamishehkar, Kamran Shadvar, Parina Asgharian, Farnaz Shahabi, Hadi Hamishehkar

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
  7. The Kidney in Heart Failure: The Role of Venous Congestion.Methodist DeBakey cardiovascular journal · 2022
    Review
  8. Inpatient Diuretic Management of Acute Heart Failure: A Practical Review.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ata MahmoodpoorDepartment of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Sahra ZahediIranian Evidence Based Medicine Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
Arezou PourakbarStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamed HamishehkarDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Kamran ShadvarDepartment of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Parina AsgharianFaculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Farnaz ShahabiDepartment of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Hadi HamishehkarDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. hamishehkar@gmail.com.
Tabriz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSome physicians co-administer albumin with loop diuretics to overcome diuretic resistance in critically ill hypoalbuminemia patients, though previous studies have reported conflicting results on this matter.

objectiveThe effects of adding albumin to furosemide to enhance its efficacy in critically ill hypoalbuminemia patients are evaluated.

methodsThis was a non-blinded randomized trial. 49 adult critically ill patients with hypoalbuminemia and generalized edema who received randomly furosemide and furosemide/albumin complex were enrolled. The patients' urine was collected at intervals of 2, 4, 6 and 8 h after initiation of the furosemide treatment, and the urine output and urinary excretion of furosemide and sodium were measured. The urinary excretion of furosemide was considered an indicator of drug efficacy.

resultsThe amount of sodium and furosemide excreted in urine showed no significant differences between the two groups; however, the mean of the urinary excretion of furosemide in the first 2 h after drug infusion was significantly higher (p = 0.03) in the furosemide/albumin group. No significant correlation between APACHE II scores and serum albumin levels and the urinary excretion of furosemide was seen.

conclusionThe results indicated that there is not statistically significant differences between groups with furosemide alone and combined with albumin in urinary furosemide excretion. It seems that adding albumin for furosemide pharmacotherapy regime is not recommended as an intervention to increase furosemide efficacy in critically ill hypoalbuminemia patients.

trial registrationIRCT with the registration number IRCT201412132582N12 in 23 February 2015; https://en.irct.ir/trial/2356 Graphical abstract.

Indexed as

AgedAged, 80 and overCritical IllnessDiureticsEdemaFemaleFurosemideHumansHypoalbuminemiaIntensive Care UnitsMaleMiddle AgedSerum AlbuminTreatment OutcomeDiureticsFurosemidefurosemide-albumin complexSerum AlbuminCritical illEdemaFurosemideHypoalbuminemia

Identifiers

PMID32291620
PMCPMC7214594
OpenAlexW3015789833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.