Evidence map›Paper›PMID 32291463›Full record

ArticleIntensive care medicine2020

COVID-19 pneumonia: different respiratory treatments for different phenotypes?

Luciano Gattinoni, Davide Chiumello, Pietro Caironi, Mattia Busana, Federica Romitti, Luca Brazzi, Luigi Camporota

12 registry-linked trialsAbstract readEditorial
In one paragraph

Article in Intensive care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 12 registered trials, which are not on this map. Cited by 988 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
988citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04411459 completednot on this map

Risk Factors for Prolonged Invasive Mechanical Ventilation in COVID-19 Acute Respiratory Distress Syndrome

TypeobservationalSponsorAzienda Usl di BolognaRan2020 to 2020Enrolled470ConditionsCOVID-19, Mechanical Ventilation, Quality of Life, Radiologic Increased Density of LungArmsInvasive mechanical ventilation
NCT04445961 completednot on this map

Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure: Multicentral Observational Study

TypeobservationalSponsorI.M. Sechenov First Moscow State Medical UniversityRan2020 to 2020Enrolled117ConditionsSARS PneumoniaArmsRespiratory mechanics measurement, Gas exchange measurement
NCT04486729 unknown statusnot on this map

Respiratory System Mechanics and Gas Exchange Characteristics Applying Different Ventilatory Strategies in Patients With SARS-CoV-2

TypeobservationalSponsorSanatorio Anchorena San MartinRan2020 to 2020Enrolled15ConditionsCovid19, ARDS, HumanArmsHigh PEEP with end inspiratory pause, Low PEEP - FiO2 high, High PEEP without end inspiratory pause, Low PEEP - FiO2 low
NCT04518969 nacompletednot on this map

Comparing the Cytokine Clearances of Pro-, and Anti-inflammatory Mediators, Chemokines and Complement in the COVID-19 Patients Treated With CytoSorb as Compared to the Same Patient Population Who do Not Receive Blood Purification Treatment

TypeinterventionalSponsorDr David DE BELSRan2020 to 2021Enrolled24ConditionsCovid19ArmsCytoSorb
NCT04524715 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Low-Level Laser Therapy Treatment of Lung Inflammation in COVID-19 Patients

TypeinterventionalSponsorWard Photonics LLCRan2021 to 2022Enrolled0ConditionsCovid19ArmsNon-invasive red LLLT treatment to chest of patient., Sham Device Treatment
NCT04692779 completednot on this mapstarted 2021, after this paper: background citation

A Prospective Clinical Study to Explore the Mechanism of Patients' Response to Prone Positioning in ARDS Patients, Including COVID-19

TypeobservationalSponsorRush University Medical CenterRan2021 to 2024Enrolled60ConditionsCovid19, ARDSArmsLung Ultrasound (LUS)
NCT04771000 phase2terminatednot on this mapstarted 2021, after this paper: background citation

A Randomised, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of Ambrisentan in Patients With Severe COVID-19

TypeinterventionalSponsorNoorik Biopharmaceuticals AGRan2021 to 2023Enrolled88ConditionsCovid19, HypoxemiaArmsAmbrisentan, Placebo
NCT04860687 unknown statusnot on this mapstarted 2021, after this paper: background citation

Quality of Life After COVID-19 Related Acute respIratory Distress Syndrome Among ICU Survivors Patients in Italy: the ODISSEA Study.

TypeobservationalSponsorAzienda Sanitaria-Universitaria Integrata di UdineRan2021 to 2021Enrolled309ConditionsCovid19, Post Traumatic Stress Disorder, Quality of Life
NCT04885517 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Dynamic Transpulmonary Pressure in Covid-19 Pneumonia: Effects of Positive Pressure, Inspired Oxygen Fraction and Decubitus

TypeinterventionalSponsorSan Luigi Gonzaga HospitalRan2021 to 2021Enrolled72ConditionsCOVID-19 PneumoniaArmsEsophageal catheter
NCT05019313 unknown statusnot on this map

Diaphragm Ultrasound Evaluation During Weaning From Mechanical Ventilation in the Positive COVID-19 Patient

TypeobservationalSponsorAzienda Sanitaria-Universitaria Integrata di UdineRan2020 to 2022Enrolled38ConditionsCOVID-19 Pneumonia, Diaphragm DiseaseArmsEvaluation of diaphragmatic contractility by ultrasound
NCT05586126 terminatednot on this map

AnaConDa-therapy in COVID-19 Patients

TypeobservationalSponsorJeroen Bosch ZiekenhuisRan2020 to 2022Enrolled42ConditionsCOVID-19, SARS CoV-2ArmsSevoflurane
NCT05630339 nacompletednot on this mapstarted 2022, after this paper: background citation

Efficacy and Security of the Magnesium and Vitamin D Combination as Adjuvant Treatment of Post-COVID Syndrome. A Randomised Double-blind Clinical Trial

TypeinterventionalSponsorCoordinación de Investigación en Salud, MexicoRan2022 to 2023Enrolled150ConditionsPost-COVID-19 Syndrome, Long COVID, Vitamin D Deficiency, Magnesium DeficiencyArmsMagnesium chloride, Vitamin D, Inert placebo
3 · Its place in the literature

Who cites it

988 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Lung Ultrasound Score in COVID-19 Patients Correlates with POThe western journal of emergency medicine · 2024
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928 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Luciano GattinoniDepartment of Anesthesiology, Intensive Care and Emergency Medicine, Medical University of Göttingen, Robert-Koch Straße 40, 37075, Göttingen, Germany. gattinoniluciano@gmail.com.
Davide ChiumelloDepartment of Anesthesia and Intensive Care, San Paolo Hospital, University of Milan, Milan, Italy.
Pietro CaironiDepartment of Anesthesia and Critical Care, Azienda Ospedaliero-Universitaria S. Luigi Gonzaga, Orbassano, Italy.
Mattia BusanaDepartment of Anesthesiology, Intensive Care and Emergency Medicine, Medical University of Göttingen, Robert-Koch Straße 40, 37075, Göttingen, Germany.
Federica RomittiDepartment of Anesthesiology, Intensive Care and Emergency Medicine, Medical University of Göttingen, Robert-Koch Straße 40, 37075, Göttingen, Germany.
Luca BrazziDepartment of Anesthesia, Intensive Care and Emergency - 'Città della Salute e della Scienza' Hospital, Turin, Italy.
Luigi CamporotaDepartment of Adult Critical Care, Guy's and St Thomas' NHS Foundation Trust, Health Centre for Human and Applied Physiological Sciences, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Airway ResistanceBetacoronavirusComorbidityCoronavirus InfectionsCOVID-19Guidelines as TopicHumansHypoxiaLungLung ComplianceOrgan SizePandemicsPhenotypePneumonia, ViralRadiography, ThoracicRespiratory Dead Space

Identifiers

PMID32291463
PMCPMC7154064

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 6 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.