Evidence map›Paper›PMID 32291302›Full record

ArticlemBio2020

YejM Modulates Activity of the YciM/FtsH Protease Complex To Prevent Lethal Accumulation of Lipopolysaccharide.

Randi L Guest, Daniel Samé Guerra, Maria Wissler, Jacqueline Grimm, Thomas J Silhavy

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Crystal Structure of Periplasmic Domain of YejM fromJournal of microbiology and biotechnology · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. The intrinsic macrolide resistome ofAntimicrobial agents and chemotherapy · 2024
    Article
  15. Review
  16. Dual function of LapB (YciM) in regulatingProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Signaling through theJournal of bacteriology · 2024
    Article
  18. Article
  19. Suppressors ofInternational journal of molecular sciences · 2023
    Article
  20. A role for the Gram-negative outer membrane in bacterial shape determination.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Randi L GuestDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, New Jersey, USA.
Daniel Samé GuerraDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, New Jersey, USA.
Maria WisslerDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, New Jersey, USA.
Jacqueline GrimmDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, New Jersey, USA.
Thomas J SilhavyDepartment of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, New Jersey, USA tsilhavy@princeton.edu.
Princeton University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007388 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 1985 to 2022
$27.4M
Biogenesis and maintenance of the outer membrane of Gram-negative bacteriaR35GM118024 · NIGMS · PRINCETON UNIVERSITY · PI SILHAVY, THOMAS J. · 2016 to 2025
$8.1M
NIGMS NIH HHS R35 GM118024NIGMS NIH HHS T32 GM007388
6 · The paper itself

Abstract

Lipopolysaccharide (LPS) is an essential glycolipid present in the outer membrane (OM) of many Gram-negative bacteria. Balanced biosynthesis of LPS is critical for cell viability; too little LPS weakens the OM, while too much LPS is lethal. In

Indexed as

ATP-Dependent ProteasesBacterial Outer Membrane ProteinsEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialLipopolysaccharidesMembrane ProteinsSignal TransductionATP-Dependent ProteasesBacterial Outer Membrane ProteinsEscherichia coli ProteinsFtsH protein, E coliLipopolysaccharidesMembrane ProteinsYciM protein, E coliYejM protein, E coliFtsHlipopolysaccharideLpxCouter membraneproteolysisYciMYejM

Identifiers

PMID32291302
PMCPMC7157816
OpenAlexW3016010874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.