Evidence map›Paper›PMID 32291301›Full record

ArticlemBio2020

Human Neutrophils Produce Antifungal Extracellular Vesicles against Aspergillus fumigatus.

Iordana A Shopova, Ivan Belyaev, Prasad Dasari, Susanne Jahreis, Maria C Stroe, Zoltán Cseresnyés, Ann-Kathrin Zimmermann, Anna Medyukhina, Carl-Magnus Svensson, Thomas Krüger and 10 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
1.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Biomolecular Corona Remodelling ofJournal of extracellular biology · 2026
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  8. Review
  9. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  10. Antifungal Innate Immunity.Advances in experimental medicine and biology · 2025
    Review
  11. Signature Proteins in Small Extracellular Vesicles of Granulocytes and CD4International journal of molecular sciences · 2024
    Article
  12. Review
  13. Article
  14. Extracellular vesicles fromMicrobiology spectrum · 2024
    Article
  15. Review
  16. Article
  17. Review
  18. International journal of molecular sciences · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Iordana A ShopovaInstitute of Microbiology, Friedrich Schiller University, Jena, Germany.
Ivan BelyaevResearch Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Prasad DasariDepartment of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Susanne JahreisClinic of Internal Medicine II, Haematology and Oncology, Jena University Hospital, Jena, Germany.
Maria C StroeInstitute of Microbiology, Friedrich Schiller University, Jena, Germany.
Zoltán CseresnyésResearch Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Ann-Kathrin ZimmermannInstitute of Microbiology, Friedrich Schiller University, Jena, Germany.
Anna MedyukhinaResearch Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Carl-Magnus SvenssonResearch Group Applied Systems Biology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Thomas KrügerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Viktòria SzeifertDepartment of Physiology, Semmelweis University, Budapest, Hungary.
Sandor NietzscheCentre for Electron Microscopy, Jena University Hospital, Jena, Germany.
Theresia ConradResearch Group Systems Biology and Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Matthew G BlangoDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Olaf KniemeyerDepartment of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Marie von Lilienfeld-ToalClinic of Internal Medicine II, Haematology and Oncology, Jena University Hospital, Jena, Germany.
Peter F ZipfelInstitute of Microbiology, Friedrich Schiller University, Jena, Germany.
Erzsébet LigetiDepartment of Physiology, Semmelweis University, Budapest, Hungary.
Marc Thilo FiggeInstitute of Microbiology, Friedrich Schiller University, Jena, Germany.
Axel A BrakhageInstitute of Microbiology, Friedrich Schiller University, Jena, Germany axel.brakhage@uni-jena.de.
Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEFriedrich Schiller University Jena · DEJena University Hospital · DESemmelweis University · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymorphonuclear granulocytes (PMNs) are indispensable for controlling life-threatening fungal infections. In addition to various effector mechanisms, PMNs also produce extracellular vesicles (EVs). Their contribution to antifungal defense has remained unexplored. We reveal that the clinically important human-pathogenic fungus

Indexed as

AdultAntimicrobial Cationic PeptidesAspergillus fumigatusBlood ProteinsCathepsin GExtracellular VesiclesHealthy VolunteersHost Microbial InteractionsHumansHyphaeMaleNeutrophilsProof of Concept StudyYoung AdultAntimicrobial Cationic PeptidesAZU1 protein, humanBlood ProteinsCathepsin GCTSG protein, humanAspergillus fumigatusazurocidincathepsin Gextracellular vesiclefluorescent image analysisfungimicrovesicleneutrophilspolymorphonuclear leukocytes

Identifiers

PMID32291301
PMCPMC7157820
OpenAlexW3015412060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.