ArticlemBio2020
Targeting Hidden Pathogens: Cell-Penetrating Enzybiotics Eradicate Intracellular Drug-Resistant Staphylococcus aureus.
Open access · goldAbstract read
In one paragraph
Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 79 citations in OpenAlex.
- Targeted delivery of peptidoglycan hydrolases (PGH) via engineered extracellular vesicles (EVs) to clear intracellular bacterial infections.Materials today. Bio · 2026Article
- Phage-derived endolysin prevents dissemination of methicillin resistantAntimicrobial agents and chemotherapy · 2026Article
- Bovine Mastitis Therapy at a Crossroads: Pharmacokinetic Barriers, Biofilms, Antimicrobial Resistance, and Emerging Solutions.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Clinical implementation of endolysins targeting gram-positive bacteria points toward a combination strategy with standard-of-care antibiotics: a selective review.European journal of medical research · 2026Review
- Avian PathogenicVeterinary sciences · 2025Review
- Review
- Harnessing intracellular bacteria in bladder by intravesical delivery of antibiotics-loaded nanodiamonds to reduce the recurrence of urinary tract infection.Journal of nanobiotechnology · 2025Article
- Lung-directed delivery of a ligand-mediated chimeric lysin has an enhanced ability to eradicate pulmonary and intracellular Staphylococcus aureus.BMC microbiology · 2025Article
- The antivirulent Staphylococcal sRNA SprC regulates CzrB efflux pump to adapt its response to zinc toxicity.RNA (New York, N.Y.) · 2024Article
- Bacteriophage as a potential biotherapeutics to combat present-day crisis of multi-drug resistant pathogens.Heliyon · 2024Review
- Bacteriophage-derived endolysins as innovative antimicrobials against bovine mastitis-causing streptococci and staphylococci: a state-of-the-art review.Acta veterinaria Scandinavica · 2024Review
- Article
- Measurement of Accumulation of Antibiotics to Staphylococcus aureus in Phagosomes of Live Macrophages.Angewandte Chemie (International ed. in English) · 2024Article
- Bacteriophage therapy for drug-resistantFrontiers in cellular and infection microbiology · 2024Review
- Development of engineered endolysins with in vitro intracellular activity against streptococcal bovine mastitis-causing pathogens.Microbial biotechnology · 2023Article
- Engineered phage with cell-penetrating peptides for intracellular bacterial infections.mSystems · 2023Article
- LYZ2-SH3b as a novel and efficient enzybiotic against methicillin-resistant Staphylococcus aureus.BMC microbiology · 2023Article
- Therapeutic potential of bacteriophage endolysins for infections caused by Gram-positive bacteria.Journal of biomedical science · 2023Review
- Bactericidal synergism between phage endolysin Ply2660 and cathelicidin LL-37 against vancomycin-resistant Enterococcus faecalis biofilms.NPJ biofilms and microbiomes · 2023Article
- Alternatives to antibiotics for treatment of mastitis in dairy cows.Frontiers in veterinary science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 2 countries.
Christian RöhrigInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Markus HuemerDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-4308-1619
Dominique LorgéInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Samuel LuterbacherInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Preeda PhothawornDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Christopher ScheferInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Anna M SobierajInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Léa V ZinsliInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Srikanth Mairpady ShambatDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Nadja LeimerDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Anja P KellerInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Fritz EichenseherInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Yang ShenInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
Sunee KorbsrisateDepartment of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Annelies S ZinkernagelDepartment of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-4700-1118
Martin J LoessnerInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.ORCID 0000-0002-8162-2631
Mathias SchmelcherInstitute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland mathias.schmelcher@hest.ethz.ch.ORCID 0000-0003-3535-3861
ETH Zurich · CHUniversity of Zurich · CHSiriraj Hospital · TH
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
3T3-L1 CellsA549 CellsAbscessAnimalsAnti-Bacterial AgentsCell-Penetrating PeptidesDrug Resistance, BacterialFemaleHumansMethicillin-Resistant Staphylococcus aureusMiceMice, Inbred C57BLMicrobial Sensitivity TestsN-Acetylmuramoyl-L-alanine AmidaseStaphylococcus aureusAnti-Bacterial AgentsCell-Penetrating PeptidesN-Acetylmuramoyl-L-alanine Amidaseantibiotic resistancebacteriophagescell-penetrating peptideendolysinintracellular bacteriaMRSApeptidoglycan hydrolasespersisterprotein therapeuticsmall-colony variantStaphylococcus aureus
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.