ArticleGenetics2020
On Negative Heritability and Negative Estimates of Heritability.
Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia.Leukemia · 2022Pooled it
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- Pitfalls in estimating and interpreting the contribution of ultra-rare genetic variants to the heritability of complex traits.medRxiv : the preprint server for health sciences · 2026Article
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- Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability.Journal of proteome research · 2025Article
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- Allele frequency impacts the cross-ancestry portability of gene expression prediction in lymphoblastoid cell lines.American journal of human genetics · 2024Article
- Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories.Nature communications · 2024Article
- 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.medRxiv : the preprint server for health sciences · 2024Article
- Causal Relationships Between Screen Use, Reading, and Brain Development in Early Adolescents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- SumVg: Total Heritability Explained by All Variants in Genome-Wide Association Studies Based on Summary Statistics with Standard Error Estimates.International journal of molecular sciences · 2024Article
- Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study.Human brain mapping · 2023Article
- Genetic Mapping for QTL Associated with Seed Nickel and Molybdenum Accumulation in the Soybean 'Forrest' by 'Williams 82' RIL Population.Plants (Basel, Switzerland) · 2023Article
- Effects of Genetic Relatedness of Kin Pairs on Univariate ACE Model Performance.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2023Article
- Genetic and environmental factors influencing neonatal resting-state functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Patterns of Volatile Diversity Yield Insights Into the Genetics and Biochemistry of the Date Palm Fruit Volatilome.Frontiers in plant science · 2022Article
- Unpredictable, Counter-Intuitive Geoclimatic and Demographic Correlations of COVID-19 Spread Rates.Biology · 2021Article
- Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.American journal of human genetics · 2021Article
- MRI-visible dilated perivascular spaces in healthy young adults: A twin heritability study.Human brain mapping · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from misspecification of the standard additive mechanism that is supposed to justify the statistical procedure. Researchers should be open to the possibility that negative heritability estimates could reflect a real physical feature of the biological process from which the data were sampled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.