ArticleReproductive biology and endocrinology : RB&E2020
Performing ICSI within 4 hours after denudation optimizes clinical outcomes in ICSI cycles.
Article in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of the time interval between oocyte retrieval and ICSI on embryo development and reproductive outcomes: a systematic review.Reproductive biology and endocrinology : RB&E · 2021Pooled it
- Immediate post-denudation intracytoplasmic sperm injection is associated with higher fertilization and early cleavage-stage embryo yield: a prospective sibling-oocyte cohort from Libyan ICSI cycles.The Libyan journal of medicine · 2026Article
- Nonlinear effects of post-denudation timing on day 3 embryo outcomes in ICSI and evidence for a translatable optimization window.Journal of translational medicine · 2026Article
- Examining the impact of denudation and ICSI timing on embryological and clinical outcomes in oocyte donation cycles.Journal of assisted reproduction and genetics · 2026Article
- Aggressive sperm immobilization improves reproductive outcomes in patients with suboptimal semen parameters and previous ICSI fertilization failure.Scientific reports · 2024Article
- Effect of the time interval between denudation and ICSI on fresh embryo transfer reproductive outcomes: a retrospective study.Frontiers in endocrinology · 2024Article
- In vivo and in vitro postovulatory aging: when time works against oocyte quality?Journal of assisted reproduction and genetics · 2022Review
- Unexplained Total Fertilization Failure after Intracytoplasmic Sperm Injection Cycles: A Case-Control Study on Predictive Factors and Retreatment Prognosis.International journal of fertility & sterility · 2022Article
- Analysis of maturation dynamics and developmental competence of in vitro matured oocytes under time-lapse monitoring.Reproductive biology and endocrinology : RB&E · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundThe study aimed to investigate whether and how general and partial time intervals between processes, from human chorionic gonadotrophin (HCG) trigger to intracytoplasmic sperm injection (ICSI), affected the laboratory and reproductive outcomes in ICSI cycles.
methodsThis was a retrospective data analysis of 3602 women who underwent ICSI treatment cycles using partner or donor sperms, performed at Reproduction Medicine Center of Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology (Wuhan, China) between October 2016 and September 2018. The clinical pregnancy rate was the major outcome in the study. The fertilization and available embryo rates were secondary outcomes.
resultsData from 3602 consecutive fresh ICSI cycles was analysed. Multivariate linear regression and logistic regression analysis of factors related to fertilization and clinical pregnancy rates showed that fertilization rate (P = 0.001) and clinical pregnancy rate (P = 0.037) were significantly associated with denudation (DN)-ICSI interval. Long DN-ICSI interval was associated with higher rate of fertilization than short DN-ICSI interval but significantly decreased clinical pregnancy rate when the interval is over 4 h (P < 0.05).
conclusionsDN-ICSI time interval can act as an independent predictor for clinical outcomes in ICSI cycles. The optimal time for ICSI is within 4 h after oocyte denudation for excellent laboratory and reproductive outcomes in ICSI cycles.
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