Trial reportBMC psychiatry2020
Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial.
Trial report in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The Cost-Effectiveness of Digitally Supported Mental Well-Being Prevention and Promotion Targeting Nonclinical Adult Populations: Systematic Review.JMIR mental health · 2025Pooled it
- Psychosocial Interventions in the Rehabilitation and the Management of Psychosis and Schizophrenia: A Systematic Review on Digitally-Delivered Interventions.Actas espanolas de psiquiatria · 2025Pooled it
- Pooled it
- Participatory research with carers: A systematic review and narrative synthesis.Health expectations : an international journal of public participation in health care and health policy · 2024Pooled it
- Psychosocial interventions for carers of people with severe mental and substance use disorders: a systematic review and meta-analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2023Pooled it
- Effect of digital psychoeducation and peer support on the mental health of family carers supporting individuals with psychosis in England (COPe-support): a randomised clinical trial.The Lancet. Digital health · 2022Trial
- Perceived Acceptability and Experiences of a Digital Psychoeducation and Peer Support Intervention (COPe-support): Interview Study With Carers Supporting Individuals With Psychosis.Journal of medical Internet research · 2022Trial
- Trial
- A web-based, peer-supported self-management intervention to reduce distress in relatives of people with psychosis or bipolar disorder: the REACT RCT.Health technology assessment (Winchester, England) · 2020Trial
- Toolkits and Toolboxes on Cancer Care and Mental Health: A Scoping Review Following the PRSMA-ScR Guidelines.Healthcare (Basel, Switzerland) · 2026Review
- A Scoping Review of Technology/Digital Support Tools for Informal Mental Health Carers: Impacts on Well being and Experience.Community mental health journal · 2026Article
- Evaluating Peer Online Forums to Support Health: Ethical and Practical Challenges.Journal of medical Internet research · 2025Article
- Barriers and Enablers to Young People's Posting, Responding, and Reading Behaviors on Mental Health Forums Using the Behavior Change Wheel: Qualitative Study.JMIR human factors · 2025Article
- Understanding the Needs of Moderators in Online Mental Health Forums: Realist Synthesis and Recommendations for Support.JMIR mental health · 2025Article
- Article
- Experiences of participation in an education and support group for carers of people with longer-term psychosis: a qualitative study.BMC psychology · 2025Article
- Article
- Understanding the Impacts of Online Mental Health Peer Support Forums: Realist Synthesis.JMIR mental health · 2024Article
- Pragmatic, feasibility randomized controlled trial of a recorded mental health recovery narrative intervention: narrative experiences online intervention for informal carers (NEON-C).Frontiers in psychiatry · 2023Article
- Clinical effectiveness of training for awareness, resilience, and action for adolescents and young adults with depression: The pilot phase of a multicenter randomized controlled trial.Frontiers in psychiatry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe Relatives Education And Coping Toolkit (REACT) is an online supported self-management toolkit for relatives of people with psychosis or bipolar designed to improve access to NICE recommended information and emotional support.
aimsOur aim was to determine clinical and cost-effectiveness of REACT including a Resource Directory (RD), versus RD-only.
methodsA primarily online, observer-blind randomised controlled trial comparing REACT (including RD) with RD only (registration ISRCTN72019945). Participants were UK relatives aged > = 16, with high distress (assessed using the GHQ-28), and actively help-seeking, individually randomised, and assessed online. Primary outcome was relatives' distress (GHQ-28) at 24 weeks. Secondary outcomes were wellbeing, support, costs and user feedback.
resultsWe recruited 800 relatives (REACT = 399; RD only = 401) with high distress at baseline (GHQ-28 REACT mean 40.3, SD 14.6; RD only mean 40.0, SD 14.0). Median time spent online on REACT was 50.8 min (IQR 12.4-172.1) versus 0.5 min (IQR 0-1.6) on RD only. Retention to primary follow-up (24 weeks) was 75% (REACT n = 292 (73.2%); RD-only n = 307 (76.6%)). Distress decreased in both groups by 24 weeks, with no significant difference between the two groups (- 1.39, 95% CI -3.60, 0.83, p = 0.22). Estimated cost of delivering REACT was £62.27 per person and users reported finding it safe, acceptable and convenient. There were no adverse events or reported side effects.
conclusionsREACT is an inexpensive, acceptable, and safe way to deliver NICE-recommended support for relatives. However, for highly distressed relatives it is no more effective in reducing distress (GHQ-28) than a comprehensive online resource directory.
trial registrationISRCTN72019945 prospectively registered 19/11/2015.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.