Evidence map›Paper›PMID 32290587›Full record

ArticleMarine drugs2020

Identification of an LPS-Induced Chemo-Attractive Peptide from

Valeria Longo, Alessandra Longo, Annamaria Martorana, Antonino Lauria, Giuseppa Augello, Antonina Azzolina, Melchiorre Cervello, Paolo Colombo

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Valeria LongoInstitute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.
Alessandra LongoInstitute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.
Annamaria MartoranaDipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", University of Palermo, Viale delle Scienze, 90128 Palermo, Italy.ORCID 0000-0002-9560-1882
Antonino LauriaDipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche "STEBICEF", University of Palermo, Viale delle Scienze, 90128 Palermo, Italy.ORCID 0000-0002-5116-6815
Giuseppa AugelloInstitute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.
Antonina AzzolinaInstitute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.
Melchiorre CervelloInstitute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.ORCID 0000-0003-4923-7220
Paolo ColomboInstitute for Biomedical Research and Innovation, National Research Council, Via Ugo La Malfa 153, 90146 Palermo, Italy.ORCID 0000-0002-0908-1359
Institute for Biomedical Research and Innovation · ITUniversity of Palermo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreviously published work has demonstrated that the LPS injection of

methodsThe 3D structure of the C8short-derived

resultsIn silico modeling showed that CrCP displayed structural characteristics already reported for a short domain of the vertebrate CRK gene, suggesting its possible involvement in cell migration mechanisms. In vitro assays demonstrated that CrCP was capable of inducing the motility of HuDe cells in both wound healing and chemo-attractive experiments. qPCR demonstrated the capability of CrCP to modulate the expression of the matrix metalloproteinase-7 (MMP-7) and E-cadherin genes. Finally, western blot analysis demonstrated that treatment with CrCP induced activation of the NF-κB signaling pathway.

conclusionOur results describe the characterization of the 3D structure and chemo-attractive activity of an LPS-induced CrCP peptide from

Indexed as

CionaAnimalsAnti-Inflammatory AgentsCell LineCell MovementLipopolysaccharidesPeptidesRNA, MessengerAnti-Inflammatory AgentsLipopolysaccharidesPeptidesRNA, Messenger3D modellingchemoattractive peptideCiona robustainflammationNF-kB

Identifiers

PMID32290587
PMCPMC7230320
OpenAlexW3015831757

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.