Evidence map›Paper›PMID 32290531›Full record

ArticleInternational journal of molecular sciences2020

Matrix Metalloproteinases: How Much Can They Do?

Magnus S Ågren, Ulrich Auf dem Keller

Open access · goldAbstract readEditorial
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  13. Identification ofInternational journal of molecular sciences · 2023
    Article
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  16. Gene Expression Linked to Reepithelialization of Human Skin Wounds.International journal of molecular sciences · 2022
    Article
  17. Vanadium Modulates Proteolytic Activities and MMP-14-Like Levels duringInternational journal of molecular sciences · 2022
    Article
  18. Article
  19. ABMC musculoskeletal disorders · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Magnus S ÅgrenDigestive Disease Center and Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen, Denmark.ORCID 0000-0002-2263-0826
Ulrich Auf dem KellerDepartment of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.ORCID 0000-0002-3431-7415
Technical University of Denmark · DKUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.

Indexed as

ADAM ProteinsAnimalsHumansMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesNeoplasmsProtein DomainsThrombospondinsADAM ProteinsMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesThrombospondinscytokinesextracellular matrixinflammationinterstitial collagensproteinaseswound healing

Identifiers

PMID32290531
PMCPMC7215854
OpenAlexW3015815503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.