Evidence map›Paper›PMID 32290523›Full record

ArticleInternational journal of molecular sciences2020

All-trans Retinoic Acid-induced Abnormal Hippocampal Expression of Synaptic Genes

Xin-Ya Qin, Hui Fang, Qing-Hong Shan, Cong-Cong Qi, Jiang-Ning Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xin-Ya QinChinese Academy of Sciences Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Hui FangChinese Academy of Sciences Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.ORCID 0000-0003-2360-7801
Qing-Hong ShanChinese Academy of Sciences Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
Cong-Cong QiDepartment of Laboratory Animal Science, Fudan University, Shanghai 200000, China.
Jiang-Ning ZhouChinese Academy of Sciences Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
University of Science and Technology of China · CNFudan University · CN

Funding

National Natural Science Foundation of China 81701327National Natural Science Foundation of China 91732304Strategic Priority Research Program of the Chinese Academy of Sciences XDB02030001
6 · The paper itself

Abstract

Clinical reports suggest a potential link between excess retinoids and development of depression. Although it has been shown that all-trans retinoic acid (ATRA) administration induces behavioral changes, further insight into how ATRA is involved is lacking. The hippocampus seems to be a major target of retinoids, and abnormal synaptic plasticity of the hippocampus is involved in depression. We examined two genes associated with synaptic function, discs large homolog 2 (

Indexed as

Age FactorsAnimalsAnxietyBiomarkersCarrier ProteinsDepressionDisease Models, AnimalGene ExpressionGuanylate KinasesHippocampusMembrane ProteinsMiceReceptors, Retinoic AcidRNA, MessengerSynapsesTretinoinBiomarkersCarrier ProteinsDlg2 protein, mouseGuanylate KinasesMembrane ProteinsReceptors, Retinoic AcidRNA, MessengerSynDIG1 protein, mouseTretinoinall-trans retinoic acidanxiety-like behaviordepression-like behaviordiscs large homolog 2hippocampussynapse differentiation-inducing gene protein 1

Identifiers

PMID32290523
PMCPMC7215843
OpenAlexW3015639191

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.