Evidence map›Paper›PMID 32290509›Full record

ArticleCells2020

Congenital Tufting Enteropathy-Associated Mutant of Epithelial Cell Adhesion Molecule Activates the Unfolded Protein Response in a Murine Model of the Disease.

Barun Das, Kevin Okamoto, John Rabalais, Ronald R Marchelletta, Kim E Barrett, Soumita Das, Maho Niwa, Mamata Sivagnanam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Barun DasDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-4669-8550
Kevin OkamotoDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.
John RabalaisDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.
Ronald R MarchellettaDepartment of Medicine, University of California, San Diego, CA 92093, USA.
Kim E BarrettDepartment of Medicine, University of California, San Diego, CA 92093, USA.
Soumita DasDepartment of Pathology, University of California, San Diego, CA 92093, USA.
Maho NiwaDivision of Biological Sciences, University of California, San Diego, CA 92093, USA.ORCID 0000-0003-3540-6249
Mamata SivagnanamDepartment of Pediatrics, University of California, San Diego, CA 92093, USA.ORCID 0000-0002-3643-1326
University of California San Diego · US

Funding

Roles of the Unfolded Protein Response in Cell CycleR01GM087415 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maho R Niwa · 2010 to 2026
$5.5M
Mutant EpCAMs role in Congenital Tufting EnteropathyR01DK107764 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIVAGNANAM, MAMATA B · 2016 to 2020
$1.7M
NIDDK NIH HHS R01 DK107764NIGMS NIH HHS R01 GM087415
6 · The paper itself

Abstract

Congenital tufting enteropathy (CTE) is a rare chronic diarrheal disease of infancy caused by mutations in epithelial cell adhesion molecule (EpCAM). Previously, a murine CTE model showed mis-localization of EpCAM away from the basolateral cell surface in the intestine. Here we demonstrate that mutant EpCAM accumulated in the endoplasmic reticulum (ER) where it co-localized with ER chaperone, GRP78/BiP, revealing potential involvement of ER stress-induced unfolded protein response (UPR) pathway in CTE. To investigate the significance of ER-localized mutant EpCAM in CTE, activation of the three UPR signaling branches initiated by the ER transmembrane protein components IRE1, PERK, and ATF6 was tested. A significant reduction in BLOS1 and SCARA3 mRNA levels in EpCAM mutant intestinal cells demonstrated that regulated IRE1-dependent decay (RIDD) was activated. However, IRE1 dependent

Indexed as

AnimalsChronic DiseaseDiarrhea, InfantileDisease Models, AnimalEndoplasmic Reticulum Chaperone BiPEpithelial Cell Adhesion MoleculeHumansInfant, NewbornMalabsorption SyndromesMiceUnfolded Protein ResponseEndoplasmic Reticulum Chaperone BiPEpithelial Cell Adhesion MoleculeHSPA5 protein, humanHspa5 protein, mousecongenital tufting enteropathyER stressmutant EpCAMunfolded protein response

Identifiers

PMID32290509
PMCPMC7226999
OpenAlexW3015935959

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.