Evidence map›Paper›PMID 32290227›Full record

ArticleMolecules (Basel, Switzerland)2020

Arylaminopropanone Derivatives as Potential Cholinesterase Inhibitors: Synthesis, Docking Study and Biological Evaluation.

Anna Hudcová, Aleš Kroutil, Renata Kubínová, Adriana D Garro, Lucas J Gutierrez, Daniel Enriz, Michal Oravec, Jozef Csöllei

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Design, synthesis, biological evaluation, and computational studies of chalcone scaffolds as cholinesterase inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Anna HudcováDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1, 61242 Brno, Czech Republic.
Aleš KroutilDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1, 61242 Brno, Czech Republic.
Renata KubínováDepartment of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1, 61242 Brno, Czech Republic.
Adriana D GarroFacultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina.
Lucas J GutierrezFacultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina.
Daniel EnrizFacultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco 915, San Luis 5700, Argentina.
Michal OravecGlobal Change Research Institute CAS, Belidla 986/4a, 60300 Brno, Czech Republic.ORCID 0000-0002-2506-5826
Jozef CsölleiDepartment of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho tr. 1, 61242 Brno, Czech Republic.
University of Veterinary Sciences Brno · CZConsejo Nacional de Investigaciones Científicas y Técnicas · ARCzech Academy of Sciences, Global Change Research Institute · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurodegenerative diseases in which the decrease of the acetylcholine is observed are growing worldwide. In the present study, a series of new arylaminopropanone derivatives with

Indexed as

Cholinesterase InhibitorsEnzyme ActivationHumansModels, MolecularMolecular ConformationMolecular Docking SimulationMolecular Dynamics SimulationMolecular StructurePropanolaminesProtein BindingStructure-Activity RelationshipCholinesterase InhibitorsPropanolaminesacetylcholinesterasearylaminopropanonebutyrylcholinesteraseenzyme assaysmolecular modellingN-phenylcarbamate

Identifiers

PMID32290227
PMCPMC7180927
OpenAlexW3015732876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.