Evidence map›Paper›PMID 32290191›Full record

ReviewJournal of functional biomaterials2020

The Role of Poly(Methyl Methacrylate) in Management of Bone Loss and Infection in Revision Total Knee Arthroplasty: A Review.

Leyla Hasandoost, Omar Rodriguez, Adel Alhalawani, Paul Zalzal, Emil H Schemitsch, Stephen D Waldman, Marcello Papini, Mark R Towler

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of functional biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. CaO-SiOMaterials (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Bioengineering (Basel, Switzerland) · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Leyla HasandoostFaculty of Engineering and Architectural Science, Biomedical Engineering Program, Ryerson University, Toronto, ON M5B 2K3, Canada.
Omar RodriguezLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.
Adel AlhalawaniLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.
Paul ZalzalFaculty of Health Sciences, Department of Surgery, McMaster University, Hamilton, ON L8S 4L8, Canada.
Emil H SchemitschLi Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1W8, Canada.
Stephen D WaldmanFaculty of Engineering and Architectural Science, Biomedical Engineering Program, Ryerson University, Toronto, ON M5B 2K3, Canada.
Marcello PapiniFaculty of Engineering and Architectural Science, Biomedical Engineering Program, Ryerson University, Toronto, ON M5B 2K3, Canada.
Mark R TowlerFaculty of Engineering and Architectural Science, Biomedical Engineering Program, Ryerson University, Toronto, ON M5B 2K3, Canada.
Toronto Metropolitan University · CASt. Michael's Hospital · CAOakville-Trafalgar Memorial Hospital · CAWestern University · CA

Funding

CIHR/NSERC - Collaborative Health Research Projects (356780-DAN). Synthesis of Bioactive Augments for use in Revision Knee Joint Replacement. 356780
6 · The paper itself

Abstract

Poly(methyl methacrylate) (PMMA) is widely used in joint arthroplasty to secure an implant to the host bone. Complications including fracture, bone loss and infection might cause failure of total knee arthroplasty (TKA), resulting in the need for revision total knee arthroplasty (rTKA). The goals of this paper are: (1) to identify the most common complications, outside of sepsis, arising from the application of PMMA following rTKA, (2) to discuss the current applications and drawbacks of employing PMMA in managing bone loss, (3) to review the role of PMMA in addressing bone infection following complications in rTKA. Papers published between 1970 to 2018 have been considered through searching in Springer, Google Scholar, IEEE Xplore, Engineering village, PubMed and weblinks. This review considers the use of PMMA as both a bone void filler and as a spacer material in two-stage revision. To manage bone loss, PMMA is widely used to fill peripheral bone defects whose depth is less than 5 mm and covers less than 50% of the bone surface. Treatment of bone infections with PMMA is mainly for two-stage rTKA where antibiotic-loaded PMMA is inserted as a spacer. This review also shows that using antibiotic-loaded PMMA might cause complications such as toxicity to surrounding tissue, incomplete antibiotic agent release from the PMMA, roughness and bacterial colonization on the surface of PMMA. Although PMMA is the only commercial bone cement used in rTKA, there are concerns associated with using PMMA following rTKA. More research and clinical studies are needed to address these complications.

Indexed as

antibiotic-loaded bone cementbone lossinfectionPMMArevision total knee arthroplasty

Identifiers

PMID32290191
PMCPMC7353497
OpenAlexW3016035440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.