Evidence map›Paper›PMID 32290170›Full record

ReviewNutrients2020

Understanding the Elements of Maternal Protection from Systemic Bacterial Infections during Early Life.

Sierra A Kleist, Kathryn A Knoop

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sierra A KleistDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Kathryn A KnoopDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2007-3066
Mayo Clinic · US

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
GUT INFLUENCES ON IMMUNE DEVELOPMENT IN EARLY LIFEK01DK109006 · NIDDK · WASHINGTON UNIVERSITY · PI KNOOP, KATHRYN A · 2016 to 2020
$637k
Neonatal immune response to gut originating pathogensR21AI144721 · NIAID · MAYO CLINIC ROCHESTER · PI KNOOP, KATHRYN A · 2020 to 2021
$437k
National Institute of Allergy and Infectious Diseases AI095542National Institute of Allergy and Infectious Diseases AI144721NIAID NIH HHS R21 AI144721NIDDK NIH HHS DK109006NIDDK NIH HHS K01 DK109006
6 · The paper itself

Abstract

Late-onset sepsis (LOS) and other systemic bloodstream infections are notable causes of neonatal mortality, particularly in prematurely born very low birth weight infants. Breastfeeding in early life has numerous health benefits, impacting the health of the newborn in both the short-term and in the long-term. Though the known benefits of an exclusive mother's own milk diet in early life have been well recognized and described, it is less understood how breastfed infants enjoy a potential reduction in risk of LOS and other systemic infections. Here we review how gut residing pathogens within the intestinal microbiota of infants can cause a subset of sepsis cases and the components of breastmilk that may prevent the dissemination of pathogens from the intestine.

Indexed as

Breast FeedingGastrointestinal MicrobiomeInfant, NewbornAnti-Bacterial AgentsContraindications, DrugDysbiosisFemaleGram-Negative BacteriaGram-Positive BacteriaHumansInfantMaleMilk, HumanNeonatal SepsisRiskAnti-Bacterial Agentsbloodstream infectionsbreastmilkenteric pathogenslate onset sepsis

Identifiers

PMID32290170
PMCPMC7230816
OpenAlexW3015384260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.