Evidence map›Paper›PMID 32290071›Full record

ArticleNutrients2020

Green Tea Polyphenol EGCG Attenuates MDSCs-mediated Immunosuppression through Canonical and Non-Canonical Pathways in a 4T1 Murine Breast Cancer Model.

Ping Xu, Feng Yan, Yueling Zhao, Xiangbo Chen, Shili Sun, Yuefei Wang, Le Ying

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Ping XuDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-1599-7408
Feng YanAustralian Centre for Blood Diseases, Central Clinical School, Monash University, Melbourne 3004, Australia.
Yueling ZhaoDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China.
Xiangbo ChenKey Laboratory of Molecular Epigenetics of the Ministry of Education, Northeast Normal University, Changchun 130024, China.
Shili SunTea Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Yuefei WangDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China.
Le YingDepartment of Tea Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-8178-7874
Zhejiang University · CNGuangdong Academy of Agricultural Sciences · CNHudson Institute of Medical Research · AUMonash University · AUNortheast Normal University · CN

Funding

Guangdong Science and Technology Department 2016B090918118
6 · The paper itself

Abstract

Several studies in the past decades have reported anti-tumor activity of the bioactive compounds extracted from tea leaves, with a focus on the compound epigallocatechin-3-gallate (EGCG). However, further investigations are required to unravel the underlying mechanisms behind the anti-tumor activity of EGCG. In this study, we demonstrate that EGCG significantly inhibits the growth of 4T1 breast cancer cells

Indexed as

PhytotherapyAnimalsArginaseBreast NeoplasmsCatechinCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalFemaleMiceMyeloid-Derived Suppressor CellsNADPH Oxidase 2NF-kappa BNitric Oxide Synthase Type IIPolyphenolsArg1 protein, mouseArginaseCatechinCybb protein, mouseepigallocatechin gallateNADPH Oxidase 2NF-kappa BNitric Oxide Synthase Type IINos2 protein, mousePolyphenolsStat3 protein, mouseSTAT3 Transcription FactorTeaanti-tumor mechanismEGCGMDSCs, immunosuppressionnon-canonical pathways

Identifiers

PMID32290071
PMCPMC7230934
OpenAlexW3015582271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.