Evidence map›Paper›PMID 32289724›Full record

ArticleBrain stimulation

Transcranial magnetic stimulation and functional magnet resonance imaging evaluation of adductor spasmodic dysphonia during phonation.

Mo Chen, Rebekah L S Summers, Cecília N Prudente, George S Goding, Sharyl Samargia-Grivette, Christy L Ludlow, Teresa J Kimberley

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05095740 narecruitingnot on this map

The Effects of Neuromodulation on Phonatory Function in Laryngeal Dystonia

TypeinterventionalSponsorMGH Institute of Health ProfessionsRan2021 to 2026Enrolled25ConditionsLaryngeal Dystonia, Focal DystoniaArmsrepetitive transcranial magnetic stimulation (rTMS), sham rTMS
NCT05580302 unknown statusnot on this map

Cortical Silent Period in Laryngeal Dystonia

Typeobservational_patient_registrySponsorUniversity of Split, School of MedicineRan2022 to 2025Enrolled20ConditionsLaryngeal Dystonia, Spasmodic DysphoniaArmsTranscranial Magnetic Stimulation (TMS)
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Spasmodic Dysphonia.World journal of otorhinolaryngology - head and neck surgery · 2025
    Review
  5. Somato-Cognitive Action Network in Focal Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mo ChenDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota. 426 Church St. SE, Minneapolis, MN, 55455, USA; Non-invasive Neuromodulation Laboratory, MnDRIVE Initiative, University of Minnesota. 247, 717 Delaware St. SE, Minneapolis, MN, 55414, USA.
Rebekah L S SummersDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota. 426 Church St. SE, Minneapolis, MN, 55455, USA; Department of Neurology, School of Medicine, University of Minnesota, 717 Delaware St., SE. Minneapolis, MN, 55414, USA.
Cecília N PrudenteDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota. 426 Church St. SE, Minneapolis, MN, 55455, USA.
George S GodingDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Phillips Wangensteen Building, 516 Delaware Street SE, Minneapolis, MN, 55455, USA.
Sharyl Samargia-GrivetteDepartment of Communication Sciences and Disorders, University of Wisconsin River Falls Campus. 220 Wyman Teacher Education Bldg, 410 South Third Street, River Falls, WI, 54022, USA.
Christy L LudlowDepartment of Communication Sciences and Disorders, James Madison University, MSC 4304, MLK Drive, Harrisonburg, VA, 22807, USA.
Teresa J KimberleyDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota. 426 Church St. SE, Minneapolis, MN, 55455, USA; School of Health and Rehabilitation Sciences, Department of Physical Therapy, Massachusetts General Hospital, Institute of Health Professions, 36 First Ave, Boston, MA, 02129, USA. Electronic address: tkimberley@mgh.harvard.edu.
University of Minnesota · USJames Madison University · USUniversity of Wisconsin–River Falls · US

Funding

A Multimodal Assessment of Neurophysiology in Focal DystoniaR01DC015216 · NIDCD · UNIVERSITY OF MINNESOTA · PI KIMBERLEY, TERESA JACOBSON · 2017 to 2021
$1.6M
The effects of neural modulation on phonatory function in laryngeal dystoniaK24DC018603 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI KIMBERLEY, TERESA JACOBSON · 2021 to 2025
$978k
Pathophysiology of Spasmodic Dysphonia: a TMS studyR21DC012344 · NIDCD · UNIVERSITY OF MINNESOTA · PI KIMBERLEY, TERESA JACOBSON · 2012 to 2013
$394k
NIDCD NIH HHS K24 DC018603NIDCD NIH HHS R01 DC015216NIDCD NIH HHS R21 DC012344
6 · The paper itself

Abstract

backgroundReduced intracortical inhibition is a neurophysiologic finding in focal dystonia that suggests a broader problem of impaired cortical excitability within the brain. A robust understanding of the neurophysiology in dystonia is essential to elucidate the pathophysiology of the disorder and develop new treatments. The cortical silent period (cSP) is a reliable, non-invasive method to measure intracortical inhibition in the primary motor cortex associated with a muscle of interest. In adductor spasmodic dysphonia (AdSD), cSP of the laryngeal motor cortex (LMC) which directly corresponds to the affected musculature, the thyroarytenoid (TA), has not been examined.

objectiveThis work evaluated the cSP of the LMC and the relationship between cSP and functional magnetic resonance imaging (fMRI) blood-oxygen-level dependent (BOLD) activation in people with AdSD (n = 12) compared to healthy controls (CTL, n = 14).

resultsShortened LMC cSP were observed bilaterally in people with AdSD vs CTL (F

conclusionIn AdSD, the cortical activation during phonation may not be efficiently or effectively associated with inhibitory processes, leading to muscular dysfunction. These findings may give insight into the maladaptive cortical control during phonation in people with AdSD.

Indexed as

AdultAgedDysphoniaFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMotor CortexPhonationTranscranial Magnetic StimulationAdductor spasmodic dysphoniaCortical silent periodLaryngeal motor cortexThyroarytenoid, laryngeal dystoniaTranscranial magnetic stimulation

Identifiers

PMID32289724
PMCPMC7213049
OpenAlexW3010772671

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.