Evidence map›Paper›PMID 32289700›Full record

ArticleBrain stimulation

Structural changes induced by electroconvulsive therapy are associated with clinical outcome.

Peter C R Mulders, Alberto Llera, Christian F Beckmann, Mathieu Vandenbulcke, Max Stek, Pascal Sienaert, Ronny Redlich, Georgios Petrides, Mardien Leoniek Oudega, Leif Oltedal and 17 more

Open access · goldAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

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  10. Mechanism of Action of ECT in Depression.Current topics in behavioral neurosciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 13 institutions in 8 countries.

Peter C R MuldersDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands. Electronic address: petercr.mulders@radboudumc.nl.
Alberto LleraDonders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands; Radboud University Nijmegen, Nijmegen, the Netherlands.
Christian F BeckmannDonders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands; Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), University of Oxford, Oxford, United Kingdom.
Mathieu VandenbulckeDepartment of Geriatric Psychiatry, University Psychiatric Center (UPC), KU Leuven, Leuven, Belgium.
Max StekGGZ InGeest Specialized Mental Health Care, Amsterdam, Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Pascal SienaertAcademic Center for ECT and Neurostimulation (AcCENT), University Psychiatric Center (UPC) - KU Leuven, Kortenberg, Belgium.
Ronny RedlichDepartment of Psychiatry, University of Münster, Münster, Germany.
Georgios Petrides- Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, USA; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, USA; Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry, Hempstead, USA.
Mardien Leoniek OudegaGGZ InGeest Specialized Mental Health Care, Amsterdam, Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Leif OltedalDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway.
Ketil J OedegaardDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Katherine L NarrDepartments of Neurology Psychiatry, Biobehavioral Sciences, Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Peter O MagnussonLund University, Box 118, SE-221 00, Lund, Sweden; Previous: Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark.
Ute KesslerDepartment of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
Anders JorgensenPsychiatric Center Copenhagen & University of Copenhagen, Copenhagen, Denmark.
Randall EspinozaDepartments of Neurology Psychiatry, Biobehavioral Sciences, Geffen School of Medicine at the University of California, Los Angeles, CA, USA.
Verena EnnekingDepartment of Psychiatry, University of Münster, Münster, Germany.
Louise EmsellDepartment of Geriatric Psychiatry, University Psychiatric Center (UPC), KU Leuven, Leuven, Belgium.
Annemieke DolsGGZ InGeest Specialized Mental Health Care, Amsterdam, Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Tom G BolwigPrevious: Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark.
Hauke BartschMohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland University Hospital, Bergen, Norway; Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA.
Miklos Argyelan- Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, USA; Center for Neuroscience, Feinstein Institute for Medical Research, Manhasset, USA; Zucker School of Medicine at Hofstra/Northwell, Department of Psychiatry, Hempstead, USA.
Amit AnandCenter of Behavioral Health, Cleveland Clinic, Cleveland, OH, USA.
Christopher C AbbottDepartment of Psychiatry, University of New Mexico, Albuquerque, NM, USA.
Philip F P van EijndhovenDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands.
Indira TendolkarDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands; Department of Psychiatry and Psychotherapy, University Hospital Essen, Essen, Germany.
Haukeland University Hospital · NORadboud University Nijmegen · NLAmsterdam Neuroscience · NLKU Leuven · BEUniversity of Münster · DEFeinstein Institute for Medical Research · USUniversity of California, Los Angeles · USCleveland Clinic · USHvidovre Hospital · DKLund University · SEUniversity of Copenhagen · DKUniversity of New Mexico · USUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElectroconvulsive therapy (ECT) is the most effective treatment option for major depressive disorder, so understanding whether its clinical effect relates to structural brain changes is vital for current and future antidepressant research.

objectiveTo determine whether clinical response to ECT is related to structural volumetric changes in the brain as measured by structural magnetic resonance imaging (MRI) and, if so, which regions are related to this clinical effect. We also determine whether a similar model can be used to identify regions associated with electrode placement (unilateral versus bilateral ECT).

methodsLongitudinal MRI and clinical data (Hamilton Depression Rating Scale) was collected from 10 sites as part of the Global ECT-MRI research collaboration (GEMRIC). From 192 subjects, relative changes in 80 (sub)cortical areas were used as potential features for classifying treatment response. We used recursive feature elimination to extract relevant features, which were subsequently used to train a linear classifier. As a validation, the same was done for electrode placement. We report accuracy as well as the structural coefficients of regions included in the discriminative spatial patterns obtained.

resultsA pattern of structural changes in cortical midline, striatal and lateral prefrontal areas discriminates responders from non-responders (75% accuracy, p < 0.001) while left-sided mediotemporal changes discriminate unilateral from bilateral electrode placement (81% accuracy, p < 0.001).

conclusionsThe identification of a multivariate discriminative pattern shows that structural change is relevant for clinical response to ECT, but this pattern does not include mediotemporal regions that have been the focus of electroconvulsive therapy research so far.

Indexed as

AdultAgedBrainElectroconvulsive TherapyFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMajor Depressive DisorderMaleMiddle AgedTreatment OutcomeDepressionElectroconvulsive therapyMajor depressive disorderMRI

Identifiers

PMID32289700
OpenAlexW3008396481

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.