ArticleBrain stimulation
Modeling transcranial electrical stimulation in the aging brain.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Outcome measures for electric field modeling in tES and TMS: A systematic review and large-scale modeling study.NeuroImage · 2023Pooled it
- Improving locomotor performance with motor imagery and tDCS in young adults.Scientific reports · 2025Trial
- Cognitive training and brain stimulation in patients with cognitive impairment: a randomized controlled trial.Alzheimer's research & therapy · 2024Trial
- Sex matters for the enhancement of cognitive training with transcranial direct current stimulation (tDCS).Biology of sex differences · 2023Trial
- Microstructural and functional plasticity following repeated brain stimulation during cognitive training in older adults.Nature communications · 2023Trial
- Combining Frontal Transcranial Direct Current Stimulation With Walking Rehabilitation to Enhance Mobility and Executive Function: A Pilot Clinical Trial.Neuromodulation : journal of the International Neuromodulation Society · 2021Trial
- Evidence against benefits from cognitive training and transcranial direct current stimulation in healthy older adults.Nature human behaviour · 2021Trial
- Effects of High Definition-Transcranial Direct Current Stimulation on Local GABA and Glutamate Levels Among Older Adults with and without Mild Cognitive Impairment: An Exploratory Study.Journal of Alzheimer's disease : JAD · 2021Trial
- Cognitive Aftereffects of Acute tDCS Coupled with Cognitive Training: An fMRI Study in Healthy Seniors.Neural plasticity · 2021Trial
- Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial.Brain stimulationTrial
- Individual differences in neuroanatomy and neurophysiology predict effects of transcranial alternating current stimulation.Brain stimulationTrial
- Machine learning and individual variability in electric field characteristics predict tDCS treatment response.Brain stimulationTrial
- tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).Brain stimulationTrial
- Focal and Steerable Temporal Interference Stimulation of the Human Left Posterior Insula: A Proof-of-Concept Validation Using Intracranial Recordings in a Human Cadaver.Bioengineering (Basel, Switzerland) · 2026Article
- 2 mA is NOT 2 mA: Electric field variability in high-definition tDCS and its implications for precision neuromodulation in aging.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Article
- Reliability of electric field simulations in different age groups: impact of data quality metrics.Brain informatics · 2026Article
- Recent Advancements of Transcranial Direct Current Stimulation and Machine Learning: Methods, Challenges, and Opportunities.Transactions on artificial intelligence · 2026Article
- Methods of Computational Modelling in Studies of Transcranial Direct Current Stimulation (tDCS) in Adults to Inform Protocols for Tinnitus Treatment: A Scoping Review.Brain sciences · 2025Review
- Dose standardization for transcranial electrical stimulation: an accessible approach.Scientific reports · 2025Article
- Learning from missteps: Potential of transcranial electrical stimulation in neuropsychological rehabilitation.Journal of neuropsychology · 2025Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundVarying treatment outcomes in transcranial electrical stimulation (tES) recipients may depend on the amount of current reaching the brain. Brain atrophy associated with normal aging may affect tES current delivery to the brain. Computational models have been employed to compute predicted tES current inside the brain. This study is the largest study that uses computational models to investigate tES field distribution in healthy older adults.
methodsIndividualized head models from 587 healthy older adults (mean = 73.9years, 51-95 years) were constructed to create field maps. Two electrode montages (F3-F4, M1-SO) with 2 mA input current were modeled using ROAST with modified codes. A customized template of healthy older adults, the UFAB-587, was created from the same dataset and used to warp individual brains into the same space. Warped models were analyzed to determine the relationship between computed field measures, brain atrophy and age. MAIN
resultsComputed field measures were inversely correlated with brain atrophy (R
conclusionsComputed field measures showed decreasing amount of tES current reaching the brain with increasing atrophy. Therefore, adjusting current dose by modifying tES stimulation parameters in older adults based on degree of atrophy may be necessary to achieve desired stimulation benefits. Results from this study may inform future tES application in healthy older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.