ReviewNeurotoxicology and teratology
Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression.
Review in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Ultra-Processed Food Consumption and Mental Health: A Systematic Review and Meta-Analysis of Observational Studies.Nutrients · 2022Pooled it
- Bisphenol A decreases peripheral insulin sensitivity in normal weight adults: a double-blind randomized controlled trial.The Journal of clinical endocrinology and metabolism · 2026Trial
- Developmental Exposure to Endocrine Disruptors and Persistent Pollutants Heightens Addiction Risk via Toxicological Mechanisms.Biomolecules & therapeutics · 2026Review
- Association between ultra-processed food consumption and odds of depression, stress, and anxiety in adolescent girls: a cross-sectional study.BMC public health · 2026Article
- Network toxicology, molecular docking and molecular dynamics simulations for bisphenol A neurotoxicity in depression pathogenesis.PloS one · 2026Article
- Interplay between prenatal bisphenol exposure, postnatal maternal care, and offspring sex in predicting DNA methylation relevant to anxiety-like behavior in rats.Hormones and behavior · 2025Article
- Early-life bisphenol A exposure causes neuronal pyroptosis in juvenile and adult male rats through the NF-κB/IL-1β/NLRP3/caspase-1 signaling pathway: exploration of age and dose as effective covariates using an in vivo and in silico modeling approach.Molecular and cellular biochemistry · 2025Article
- The influence of economic policies on social environments and mental health.Bulletin of the World Health Organization · 2024Article
- Phenols and GABAFrontiers in pharmacology · 2024Review
- Article
- The passive avoidance task ameliorate the toxic effects of bisphenol A on dopamine D1 receptor density in hippocampus, amygdala, and cerebellum of male rats.Brain and behavior · 2023Article
- Environmental chemical exposures and mental health outcomes in children: a narrative review of recent literature.Frontiers in toxicology · 2023Review
- Article
- Neurotoxicants, the Developing Brain, and Mental Health.Biological psychiatry global open science · 2022Article
- Can Antioxidants Reduce the Toxicity of Bisphenol?Antioxidants (Basel, Switzerland) · 2022Review
- Environment in Children's Health: A New Challenge for Risk Assessment.International journal of environmental research and public health · 2021Review
- Anti-anxiety and antidepressant-like effects of astragaloside IV and saponins extracted from Astragalus spinosus against the bisphenol A-induced motor and cognitive impairments in a postnatal rat model of schizophrenia.Environmental science and pollution research international · 2021Article
- Applications of the SR4G Transgenic Zebrafish Line for Biomonitoring of Stress-Disrupting Compounds: A Proof-of-Concept Study.Frontiers in endocrinology · 2021Article
- White rot fungi can be a promising tool for removal of bisphenol A, bisphenol S, and nonylphenol from wastewater.Environmental science and pollution research international · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Endocrine-disrupting compounds (EDCs) are common contaminants in our environment that interfere with typical endocrine function. EDCs can act on steroid and nuclear receptors or alter hormone production. One particular EDC of critical concern is bisphenol A (BPA) due to its potential harm during the perinatal period of development. Previous studies suggest that perinatal exposure to BPA alters several neurotransmitter systems and disrupts behaviors associated with depression and anxiety in the rodent offspring later in life. Thus, dysregulation in neurotransmission may translate to behavioral phenotypes observed in mood and arousal. Many of the systems disrupted by BPA also overlap with the stress system, although little evidence exists on the effects of perinatal BPA exposure in relation to stress and behavior. The purpose of this review is to explore studies involved in perinatal BPA exposure and the stress response at neurochemical and behavioral endpoints. Although more research is needed, we suggest that perinatal BPA exposure is likely inducing variations in behavioral phenotypes that modulate their action through dysregulation of neurotransmitter systems sensitive to stress and endocrine disruption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.