ArticleCell2020
The Crystal Structure of a Biological Insulated Transmembrane Molecular Wire.
Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 205 citations in OpenAlex.
- Novel taxa of Acidobacteriota implicated in seafloor sulfur cycling.The ISME journal · 2021Pooled it
- Conjugated Polymer-Microbe Interactions Trigger Regulatory Reprogramming for Enhanced Bioelectrocatalysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Comparative transcriptomics and scarless genome editing uncover a periplasmicApplied and environmental microbiology · 2026Article
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- Lysine or histidine? examining the role of the proximal ligand at the active heme center of cytochrome c nitrite reductase.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Azurins With Tunable Reduction Potentials as Redox Mediators for Extracellular Electron Transfer.Chembiochem : a European journal of chemical biology · 2026Article
- Inspiration from humans and microbes-and maybe a lot of luck: the "discovery" ofJournal of bacteriology · 2026Review
- Metabolic diversity of Ferrovaceae and potential contributions to iron oxidation.Applied and environmental microbiology · 2026Article
- Expression and Engineering of Conductive Cytochrome Nanowires.bioRxiv : the preprint server for biology · 2026Article
- Designing Microbe-Semiconductor Interfaces for Semibiological Photosynthesis.Chemical reviews · 2026Review
- Engineering electron conduits in bacteria for selective biointerfacing and enhanced energy transfer.iScience · 2026Article
- Spatiotemporal organization of membrane protein controls bacterial extracellular electron transfer.Nature communications · 2026Article
- Cytochrome nanowires under electron microscopy.Emerging topics in life sciences · 2026Review
- Photocatalytic Biohybrid Vesicles.Chemical reviews · 2026Review
- The conserved two-component systems CutRS and CssRS control the protein secretion stress response inmBio · 2026Article
- Cell-Surface Inter-Cytochrome Electron Transfer Limits Biofilm Electron Conduction Kinetics inJournal of the American Chemical Society · 2025Article
- Redox conduction facilitates direct interspecies electron transport in anaerobic methanotrophic consortia.Science advances · 2025Article
- Extracellular catalysis of environmental substrates by Shewanella oneidensis MR-1 occurs via active sites on the C-terminal domains of MtrC.Protein science : a publication of the Protein Society · 2025Article
- Energetic constraints of metal-reducing bacteria as biocatalysts for microbial electrosynthesis.Biotechnology for biofuels and bioproducts · 2025Article
- A Bioelectrochemical Crossbar Architecture Screening Platform (BiCASP) for Extracellular Electron Transfer.bioRxiv : the preprint server for biology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
A growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this process remain unknown. Here, we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a protein family known to transport electrons between the interior and exterior environments of phylogenetically and metabolically diverse microorganisms. The structure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand β-barrel formed by MtrB. MtrAB forms an intimate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact with extracellular redox partners, including transition metals and electrodes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.