ArticleNeuron2020
Spaced Training Forms Complementary Long-Term Memories of Opposite Valence in Drosophila.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 116 citations in OpenAlex.
- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- Unforgettable forgotten memories.Nature neuroscience · 2026Article
- Aberrant dopaminergic activity during consolidation causes age-related memory generalization in Drosophila.PLoS biology · 2026Article
- A voltage-dependent switch underlies efficient yet specific learning and memory.Current biology : CB · 2026Article
- Article
- Heliconiini butterflies display flight behaviours reminiscent of orientation flights when using new floral sources.The Journal of experimental biology · 2025Article
- dArc1 controls sugar reward valuation in Drosophila melanogaster.Current biology : CB · 2025Article
- Twists to Classical Conditioning of AdultCold Spring Harbor protocols · 2025Article
- Article
- What could evolve in the evolution of memory?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Long-term social memory of mate copying in Drosophila melanogaster is localized in mushroom bodies.Scientific reports · 2025Article
- Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning.Science advances · 2024Article
- Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling.Nature communications · 2024Article
- Dopamine neurons that inform Drosophila olfactory memory have distinct, acute functions driving attraction and aversion.PLoS biology · 2024Article
- Article
- Review
- Article
- Reinforcement learning when your life depends on it: A neuro-economic theory of learning.PLoS computational biology · 2024Article
- Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila.Neuron · 2024Article
- PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Forming long-term memory (LTM) often requires repetitive experience spread over time. Studies in Drosophila suggest aversive olfactory LTM is optimal after spaced training, multiple trials of differential odor conditioning with rest intervals. Memory after spaced training is frequently compared to that after the same number of trials without intervals. Here we show that, after spaced training, flies acquire additional information and form an aversive memory for the shock-paired odor and a slowly emerging and more persistent "safety-memory" for the explicitly unpaired odor. Safety-memory acquisition requires repetition, order, and spacing of the training trials and relies on triggering specific rewarding dopaminergic neurons. Co-existence of aversive and safety memories is evident as depression of odor-specific responses at different combinations of junctions in the mushroom body output network; combining two outputs appears to signal relative safety. Having complementary aversive and safety memories augments LTM performance after spaced training by making the odor preference more certain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.