Evidence map›Paper›PMID 32289229›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

S1P

Carole-Ann Huppé, Pascale Blais-Lecours, Emilie Bernatchez, Jean-François Lauzon-Joset, Caroline Duchaine, Hugh Rosen, Geneviève Dion, Kelly M McNagny, Marie-Renée Blanchet, Mathieu C Morissette and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. How experimental models have unlocked hidden mechanisms of hypersensitivity pneumonitis.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Carole-Ann HuppéCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Pascale Blais-LecoursCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Emilie BernatchezCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Jean-François Lauzon-JosetCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Caroline DuchaineCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Hugh RosenDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California; and.
Geneviève DionCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Kelly M McNagnyThe Biomedical Research Center, University of British Columbia, Vancouver, British Columbia, Canada.
Marie-Renée BlanchetCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Mathieu C MorissetteCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
David MarsolaisCentre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Québec, Québec, Canada.
Institut universitaire de cardiologie et de pneumologie de Québec · CAScripps Research Institute · USUniversity of British Columbia · CA

Funding

Optimization of S1P3 antagonists for fibrotic diseaseR01AR069877 · NIAMS · SCRIPPS RESEARCH INSTITUTE, THE · PI ROSEN, HUGH · 2016 to 2018
$1.8M
CIHRNIAMS NIH HHS R01 AR069877
6 · The paper itself

Abstract

In a proportion of patients with hypersensitivity pneumonitis, the biological and environmental factors that sustain inflammation are ill defined, resulting in no effective treatment option. Bioaerosols found in occupational settings are complex and often include Toll-like receptor ligands, such as endotoxins. How Toll-like receptor ligands contribute to the persistence of hypersensitivity pneumonitis, however, remains poorly understood. In a previous study, we found that an S1P

Indexed as

Alveolitis, Extrinsic AllergicAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteB-LymphocytesCD69 AntigensEndotoxinsFemaleLectins, C-TypeLymphocyte ActivationMiceNeutrophilsSphingosine-1-Phosphate ReceptorsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensEndotoxinsLectins, C-TypeSphingosine-1-Phosphate Receptorsantibodiesextrinsic allergic alveolitisozanimodTLR4TNF

Identifiers

PMID32289229
PMCPMC7464516
OpenAlexW3015589720

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.