Evidence map›Paper›PMID 32289057›Full record

ArticleMicrobial risk analysis2019

Towards a thermodynamic mechanistic model for the effect of temperature on arthropod vector competence for transmission of arboviruses.

Paul Gale

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial risk analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 56 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Paul Gale15 Weare Close, Portland, Dorset DT5 1JP, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arboviruses such as West Nile virus (WNV), bluetongue virus (BTV), dengue virus (DENV) and chikungunya virus (CHIKV) infect their arthropod vectors over a range of average temperatures depending on the ambient temperature. How the transmission efficiency of an arbovirus (i.e. vector competence) varies with temperature influences not only the short term risk of arbovirus outbreaks in humans and livestock but also the long term impact of climate change on the geographical range of the virus. The strength of the interaction between viral surface (glyco)protein (GP) and the host cell receptor (Cr) on binding of virus to host cell is defined by the thermodynamic dissociation constant K

Indexed as

AIV, avian influenza virusArbovirusBBF, brush border fragments from midgutCfree, number of midgut epithelial cells which can bind virus with no virus boundCHIKV, chikungunya virusCr, host cell receptorCtotal_midgut, number of midgut epithelial cells which can bind virusC.VT, number of arthropod midgut cells with bound arbovirus at temperature TDENV, dengue fever virusEA, activation energyEBOV, Zaire ebolavirusEIP, extrinsic incubation periodEnthalpyEntropyFc, fraction of arthropod midgut cells with bound virus at temperature TGP, viral (glyco)protein on virus surface that binds to CrHA, haemagglutininHRV3, human rhinovirus serotype 3ICAM-1, intercellular adhesion molecule-1IDR, intrinsically disordered region of a proteinKa, binding affinity for virus to host cells at temperature TKd_receptor, dissociation constant for GP from CrKd_virus, dissociation constant for virus from host cellk, rate of reactionM, molar (moles dm−3)NA, neuraminidasen, number of GP/Cr contacts made on virus binding to cellpcompleteT, probability, given a virion has bound to the surface of a midgut cell, that that midgut cell becomes infected and that its progeny viruses go on to infect the salivary gland so completing the arthropod infection process within the life time of the arthropod at temperature Tpfu, plaque-forming unitptransmissionT, probability of successful infection of the arthropod salivary glands given oral exposure at temperature TRdRp, RNA dependent RNA polymeraseR, ideal gas constantSA, sialic acidTemperatureVector competenceVEEV, Venezuelan equine encephalitis virusVfree, virus not bound to cellsVSV, vesicular stomatitis virusVtotal, virus challenge dose to midgutWEEV, Western equine encephalitis virusWNV, West Nile virusΔGa_receptor, change in Gibbs free energy on association of GP and Cr receptorΔHa_receptor, change in enthalpy for binding of virus GP to host Cr receptorΔHa_virus, change in enthalpy for binding of virus to host cellΔSa_immob, change in entropy on immobilization of virus to cell surfaceΔSa_receptor, change in entropy for binding of virus GP to host Cr receptorΔSa_virus, change in entropy for binding of virus to host cellΔSconf, change in conformation entropy within GP or Cr

Identifiers

PMID32289057
PMCPMC7104215
OpenAlexW2920385608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.