ArticleScience bulletin2018
Severe human infection with a novel avian-origin influenza A(H7N4) virus.
Article in Science bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Virulence and transmission characteristic of H3N8 avian influenza virus circulating in chickens in China.Virulence · 2026Article
- A neutralizing nanobody targeting a conserved lateral patch on HA1 confers protection against multiple H7 avian influenza viruses.Journal of virology · 2026Article
- Epidemiological and Virological Characteristics of H9N2 Avian Influenza Virus in Jiangsu Province, China, 2024.Viruses · 2026Article
- North American-origin influenza A (H10) viruses in Eurasian wild birds (2022-2024): implications for the emergence of human H10N5 virus.Emerging microbes & infections · 2025Article
- Viral factors underlying the pandemic potential of influenza viruses.Microbiology and molecular biology reviews : MMBR · 2025Review
- E627V mutation in PB2 protein promotes the mammalian adaptation of novel H10N3 avian influenza virus.Veterinary research · 2025Article
- Article
- Evolution and biological characteristics of H11 avian influenza viruses isolated from migratory birds and pigeons.Emerging microbes & infections · 2024Article
- H7N6 highly pathogenic avian influenza in Mozambique, 2023.Emerging microbes & infections · 2024Article
- Effects of different HA and NA gene combinations on the growth characteristics of the H3N8 influenza candidate vaccine virus.Vaccine: X · 2024Article
- Potential zoonotic spillover at the human-animal interface: A mini-review.Veterinary world · 2024Review
- Ecological and Genetic Landscapes of Global H12 Avian Influenza Viruses and Biological Characteristics of an H12N5 Virus Isolated from Wild Ducks in Eastern China.Transboundary and emerging diseases · 2024Article
- Alarming situation of emerging H5 and H7 avian influenza and effective control strategies.Emerging microbes & infections · 2023Review
- Human infection with a reassortment avian influenza A H3N8 virus: an epidemiological investigation study.Nature communications · 2022Article
- Homologous PB1 gene promotes the replication efficiency of avian influenza H7N4 candidate vaccine virus.Influenza and other respiratory viruses · 2022Article
- Emerging HxNy Influenza A Viruses.Cold Spring Harbor perspectives in medicine · 2022Review
- Article
- Genetic Characterization and Pathogenicity of H7N7 and H7N9 Avian Influenza Viruses Isolated from South Korea.Viruses · 2021Article
- Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic.Frontiers of medicine · 2021Review
- Article
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient. We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets (LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry (chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.