Evidence map›Paper›PMID 32288791›Full record

ReviewJournal of functional foods2017

Kaempferol - A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements.

Dharambir Kashyap, Ajay Sharma, Hardeep Singh Tuli, Katrin Sak, Sandeep Punia, Tapan K Mukherjee

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of functional foods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
14.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 211 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  13. Protective Effects ofAntioxidants (Basel, Switzerland) · 2025
    Article
  14. Review
  15. Evaluation ofJournal of pharmacopuncture · 2025
    Article
  16. Review
  17. Hepatoprotective Effect of Kaempferol-A Review.Molecules (Basel, Switzerland) · 2025
    Review
  18. Article
  19. Article
  20. Review

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Dharambir KashyapDepartment of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab 160012, India.
Ajay SharmaDepartment of Chemistry, Career Point University, Tikker - kharwarian, Hamirpur, Himachal Pradesh 176041, India.
Hardeep Singh TuliDepartment of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, India.
Katrin SakNGO Praeventio, Tartu, Estonia.
Sandeep PuniaDepartment of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, India.
Tapan K MukherjeeDepartment of Biotechnology, Maharishi Markandeshwar University, Mullana-Ambala, Haryana, India.
Maharishi Markandeshwar University, Mullana · INCareer Point University · INPost Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The consumption of diet-based naturally bioactive metabolites is preferred to synthetic material in order to avert health-associated disorders. Among the plant-derived polyphenols, kaempferol (KMF) is considered as a valuable functional food ingredient with a broad range of therapeutic applications such as anti-cancer, antioxidant and anti-inflammatory uses. KMF acts on a range of intracellular as well as extracellular targets involved in the cell signaling pathways that in turn are known to regulate the hallmarks of cancer growth progressions like apoptosis, cell cycle, invasion or metastasis, angiogenesis and inflammation. Importantly, the understanding of mechanisms of action of KMF-mediated therapeutic effects may help the scientific community to design novel strategies for the treatment of dreadful diseases. The current review summarizes the various types of molecular targets of KMF in cancer cells as well as other health-associated disorders. In addition, this review also highlights the absorption, metabolism and epidemiological findings.

Indexed as

Anti-angiogenesisAnti-inflammationAnti-metastasisAnti-proliferativeKaempferolSynergism

Identifiers

PMID32288791
PMCPMC7104980
OpenAlexW2573899154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.