Evidence map›Paper›PMID 32288594›Full record

ArticleProcess biochemistry (Barking, London, England)2018

Gene-silencing suppressors for high-level production of the HIV-1 entry inhibitor griffithsin in

Peyman Habibi, Carlos Ricardo Soccol, Barry R O'Keefe, Lauren R H Krumpe, Jennifer Wilson, Leonardo Lima Pepino de Macedo, Muhammad Faheem, Vanessa Olinto Dos Santos, Guilherme Souza Prado, Marco Antonio Botelho and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Process biochemistry (Barking, London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  5. Article
  6. Lectins and lectibodies: potential promising antiviral agents.Cellular & molecular biology letters · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 3 countries.

Peyman HabibiDepartment of Bioprocess Engineering and Biotechnology, Federal University of Paraná, Curitiba, PR, Brazil.
Carlos Ricardo SoccolDepartment of Bioprocess Engineering and Biotechnology, Federal University of Paraná, Curitiba, PR, Brazil.
Barry R O'KeefeMolecular Targets Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Lauren R H KrumpeBasic Science Program, Leidos Biomedical Research, Inc., Molecular Targets Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Jennifer WilsonMolecular Targets Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Leonardo Lima Pepino de MacedoEmbrapa Genetic Resources and Biotechnology, PqEB-Final W5 Norte - CP 02372, Brasília-DF, Brazil.
Muhammad FaheemEmbrapa Genetic Resources and Biotechnology, PqEB-Final W5 Norte - CP 02372, Brasília-DF, Brazil.
Vanessa Olinto Dos SantosEmbrapa Genetic Resources and Biotechnology, PqEB-Final W5 Norte - CP 02372, Brasília-DF, Brazil.
Guilherme Souza PradoEmbrapa Genetic Resources and Biotechnology, PqEB-Final W5 Norte - CP 02372, Brasília-DF, Brazil.
Marco Antonio BotelhoPost Graduation Program in Biotechnology, University Potiguar, Natal, RN, Brazil.
Severine LacombeIRD, CIRAD, Universite Montpellier, Interactions Plantes Microorganismes et Environnement (IPME), Montpellier, France.
Maria Fatima Grossi-de-SaEmbrapa Genetic Resources and Biotechnology, PqEB-Final W5 Norte - CP 02372, Brasília-DF, Brazil.
Brazilian Agricultural Research Corporation · BRTarget (United States) · USCentre de Coopération Internationale en Recherche Agronomique pour le Développement · FRFrederick National Laboratory for Cancer Research · USUniversidade Católica de Brasília · BRUniversidade Federal do Paraná · BRUniversidade Potiguar · BR

Funding

CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

The exploration of emerging host organisms for the economic and efficient production of protein microbicides against HIV is urgently needed in resource-poor areas worldwide. In this study, the production of the novel HIV entry inhibitor candidate,

Indexed as

AgroinfiltrationE. coliGRFTHIV-1Nicotiana benthamianaSilencing suppressors

Identifiers

PMID32288594
PMCPMC7108441
OpenAlexW2796664329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.