ArticleSensors and actuators. B, Chemical2014
Methylene blue covalently attached to single stranded DNA as electroactive label for potential bioassays.
Article in Sensors and actuators. B, Chemical, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- A Novel 3D-Printed Flow Cell Design forMicromachines · 2026Article
- Methylene blue as a new signal tracer for nucleic acid-based lateral flow assay.Scientific reports · 2025Article
- Article
- Development of Sensitive Methods for the Detection of Minimum Concentrations of DNA on Martian Soil Simulants.Life (Basel, Switzerland) · 2023Article
- A Review of Detection Methods for Vancomycin-ResistantBiosensors · 2023Review
- Longer amplicons provide better sensitivity for electrochemical sensing of viral nucleic acid in water samples using PCB electrodes.Scientific reports · 2022Article
- Emerging materials for the electrochemical detection of COVID-19.Journal of electroanalytical chemistry (Lausanne, Switzerland) · 2021Review
- Ultrasensitive Materials for Electrochemical Biosensor Labels.Sensors (Basel, Switzerland) · 2020Review
- The potential of electrochemistry for the detection of coronavirus-induced infections.Trends in analytical chemistry : TRAC · 2020Review
- Folding-Based Electrochemical Aptasensor for the Determination of β-Lactoglobulin on Poly-L-Lysine Modified Graphite Electrodes.Sensors (Basel, Switzerland) · 2020Article
- Methylene blue covalently attached to single stranded DNA as electroactive label for potential bioassays.Sensors and actuators. B, Chemical · 2014Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylene blue is an electroactive molecule that has been employed for the detection of the DNA hybridization event in electrochemical sensors. However, its use as a covalent label is very scarce and in most of the cases, non-covalent interactions (hydrophobic, electrostatic) are employed. Although it has advantages as simplicity and fewer number of procedure steps, the covalent attachment is less exploited in the development of these sensors. In this article, the electrochemical behavior of methylene blue attached to different DNA-strands is studied. Several lengths (15- and 30-mer) and different degree of DNA modification (MB-DNA, MB-DNA-MB and MB-DNA-SH) have been studied. The highest signals were obtained for longer strands with two MB molecules. In all the cases the signal is enhanced by CNT-nanostructuration of the electrode. Adsorption on these modified screen-printed electrodes allowed the amplification by employing an accumulation time. In this way, a sensitivity of -0.2864 μA μM
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