Evidence map›Paper›PMID 32287568›Full record

ArticleMicroelectronic engineering2018

Diagnostic tools for tackling febrile illness and enhancing patient management.

Konstantinos Mitsakakis, Valérie D'Acremont, Sebastian Hin, Felix von Stetten, Roland Zengerle

Abstract read
In one paragraph

Article in Microelectronic engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Konstantinos MitsakakisHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Valérie D'AcremontSwiss Tropical and Public Health Institute, University of Basel, Socinstrasse 57, 4002 Basel, Switzerland.
Sebastian HinHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Felix von StettenHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.
Roland ZengerleHahn-Schickard, Georges-Koehler-Allee 103, 79110 Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most patients with acute infectious diseases develop fever, which is frequently a reason to visit health facilities in resource-limited settings. The symptomatic overlap between febrile diseases impedes their diagnosis on clinical grounds. Therefore, the World Health Organization promotes an integrated management of febrile illness. Along this line, we present an overview of endemic and epidemic etiologies of fever and state-of-the-art diagnostic tools used in the field. It becomes evident that there is an urgent need for the development of novel technologies to fulfill end-users' requirements. This need can be met with point-of-care and near-patient diagnostic platforms, as well as e-Health clinical algorithms, which co-assess test results with key clinical elements and biosensors, assisting clinicians in patient triage and management, thus enhancing disease surveillance and outbreak alerts. This review gives an overview of diagnostic technologies featuring a platform based approach: (i) assay (nucleic acid amplification technologies are examined); (ii) cartridge (microfluidic technologies are presented); (iii) instrument (various detection technologies are discussed); and at the end proposes a way that such technologies can be interfaced with electronic clinical decision-making algorithms towards a broad and complete diagnostic ecosystem.

Indexed as

Disease surveillanceElectronic clinical decision algorithmsFebrile illnessMicrofluidicsNucleic acid amplificationPoint-of-care diagnostics

Identifiers

PMID32287568
PMCPMC7114275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.