Evidence map›Paper›PMID 32287535›Full record

ReviewTrends in analytical chemistry : TRAC2011

Selection and analytical applications of aptamers binding microbial pathogens.

Camille L A Hamula, Hongquan Zhang, Feng Li, Zhixin Wang, X Chris Le, Xing-Fang Li

Abstract readReview
In one paragraph

Review in Trends in analytical chemistry : TRAC, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. RSC advances · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Analysis ofFrontiers in cellular and infection microbiology · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Recent Advances in Aptasensors For Rapid and Sensitive Detection ofFrontiers in bioengineering and biotechnology · 2022
    Review
  13. Article
  14. Review
  15. Article
  16. Nucleic Acids Analysis.Science China. Chemistry · 2021
    Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camille L A HamulaDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Bldg., University of Alberta, Edmonton, Alberta, Canada T6G 2G3.
Hongquan ZhangDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Bldg., University of Alberta, Edmonton, Alberta, Canada T6G 2G3.
Feng LiDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Bldg., University of Alberta, Edmonton, Alberta, Canada T6G 2G3.
Zhixin WangDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Bldg., University of Alberta, Edmonton, Alberta, Canada T6G 2G3.
X Chris LeDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Bldg., University of Alberta, Edmonton, Alberta, Canada T6G 2G3.
Xing-Fang LiDivision of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine and Dentistry, 10-102 Clinical Sciences Bldg., University of Alberta, Edmonton, Alberta, Canada T6G 2G3.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

DNA aptamers specifically recognizing microbial cells and viruses have a range of analytical and therapeutic applications. This article describes recent advances in the development of aptamers targeting specific pathogens (e.g., live bacteria, whole viral particles, and virally-infected mammalian cells). Specific aptamers against pathogens have been used as affinity reagents to develop sandwich assays, to label and to image cells, to bind with cells for flow-cytometry analysis, and to act as probes for development of whole-cell biosensors. Future applications of aptamers to pathogens will benefit from recent advances in improved selection and new aptamers containing modified nucleotides, particularly slow off-rate modified aptamers (SOMAmers).

Indexed as

AptamerBacteriaBioanalytical assayBiosensorDNAIn-vitro selectionPathogenProteinSELEXSOMAmer

Identifiers

PMID32287535
PMCPMC7112775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.