ArticlePLoS pathogens2020
Characterizing Emerging Canine H3 Influenza Viruses.
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Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
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Who cites it
33 citing papers in PubMed, 44 citations in OpenAlex.
- Antibody-free detection of influenza viruses on a microarray to study their receptor specificity.Archives of virology · 2026Article
- Molecular Characterization of an H3N2 Canine Influenza Virus Isolated from a Dog in Jiangsu, China, in 2025.Veterinary sciences · 2025Article
- Phylogenetic and Molecular Characteristics of An H3N8 Avian Influenza Virus Detected in Wild Birds - Beijing, China, September 2024.China CDC weekly · 2025Article
- Intranasal NS1-truncated live attenuated canine influenza vaccine confers superior protection compared to inactivated vaccine in beagles.Veterinary research · 2025Article
- Viral characterization of the reassortants between canine influenza H3N2 and human pandemic (2009) H1N1 and avian H9N2 viruses in canine ex vivo tracheal explants.Virology journal · 2025Article
- The evolution and epidemiology of H3N2 canine influenza virus after 20 years in dogs.Epidemiology and infection · 2025Article
- Pathogenicity of Novel H3 Avian Influenza Viruses in Chickens and Development of a Promising Vaccine.Viruses · 2025Article
- Observational
- The global H5N1 influenza panzootic in mammals.Nature · 2025Review
- The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly.Emerging microbes & infections · 2024Article
- Adaptation potential of H3N8 canine influenza virus in human respiratory cells.Scientific reports · 2024Article
- The V223I substitution in hemagglutinin reduces the binding affinity to human-type receptors while enhancing the thermal stability of the H3N2 canine influenza virus.Frontiers in microbiology · 2024Article
- Prevalence, evolution, replication and transmission of H3N8 avian influenza viruses isolated from migratory birds in eastern China from 2017 to 2021.Emerging microbes & infections · 2023Article
- Two Decades of Arrayed Imaging Reflectometry for Sensitive, High-Throughput Biosensing.Biosensors · 2023Review
- Mapping antibody footprints using binding profiles.Cell reports methods · 2023Article
- Review
- Article
- Increased public health threat of avian-origin H3N2 influenza virus caused by its evolution in dogs.eLife · 2023Article
- Zoonosis and zooanthroponosis of emerging respiratory viruses.Frontiers in cellular and infection microbiology · 2023Review
- Understanding the divergent evolution and epidemiology of H3N8 influenza viruses in dogs and horses.Virus evolution · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
84 authors at 15 institutions in 6 countries.
Luis Martinez-SobridoDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America.ORCID 0000-0001-7084-0804
Pilar Blanco-LoboDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America.
Laura RodriguezDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America.
Theresa FitzgeraldDavid H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America.
Hanyuan ZhangDepartment of Dermatology, University of Rochester, Rochester, New York, United States of America.ORCID 0000-0002-0736-4603
Phuong NguyenDavid H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America.ORCID 0000-0002-8273-730X
Christopher S AndersonDavid H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America.ORCID 0000-0002-8560-3438
Jeanne Holden-WiltseDepartment of Biostatistics and Computational Biology and Clinical and Translational Science Institute, University of Rochester, Rochester, New York, United States of America.ORCID 0000-0003-2694-7465
Sanjukta BandyopadhyayDepartment of Biostatistics and Computational Biology and Clinical and Translational Science Institute, University of Rochester, Rochester, New York, United States of America.
Aitor NogalesDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America.
Marta L DeDiegoDavid H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America.
Brian R WasikBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America.ORCID 0000-0001-5442-3883
Benjamin L MillerDepartment of Dermatology, University of Rochester, Rochester, New York, United States of America.ORCID 0000-0001-9168-8047
Carole HenryThe Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0002-5696-527X
Patrick C WilsonThe Department of Medicine, Section of Rheumatology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0002-3537-1245
Mark Y SangsterDavid H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America.
John J TreanorDavid H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America.
David J TophamDavid H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, New York, United States of America.ORCID 0000-0002-9435-8673
Lauren Byrd-LeotisDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.ORCID 0000-0002-7984-0357
David A SteinhauerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Richard D CummingsDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.ORCID 0000-0002-8918-5034
Jasmina M LuczoCenter for Vaccines and Immunology, University of Georgia, Athens, Georgia, United States of America.ORCID 0000-0002-8036-110X
Stephen M TompkinsCenter for Vaccines and Immunology, University of Georgia, Athens, Georgia, United States of America.ORCID 0000-0002-1523-5588
Kaori SakamotoDepartment of Pathology, University of Georgia, Athens, Georgia, United States of America.ORCID 0000-0003-0592-6403
Cheryl A JonesCenter for Vaccines and Immunology, University of Georgia, Athens, Georgia, United States of America.
John SteelDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.ORCID 0000-0003-1217-0990
Anice C LowenDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Shamika DanzyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Hui TaoDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Ashley L FinkW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Sabra L KleinW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.ORCID 0000-0002-0730-5224
Nicholas WohlgemuthW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.ORCID 0000-0002-6450-6452
Katherine J FenstermacherW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.ORCID 0000-0003-1139-3711
Farah El NajjarW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Andrew PekoszW. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.ORCID 0000-0003-3248-1761
Lauren SauerDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Mitra K LewisDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.ORCID 0000-0002-4737-4961
Kathryn Shaw-SalibaDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Richard E RothmanDepartment of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
Zhen-Ying LiuDepartment of Emergency Medicine, Chang Gung Memorial Hospital, Taiwan.
Kuan-Fu ChenDepartment of Emergency Medicine, Chang Gung Memorial Hospital, Taiwan.ORCID 0000-0001-7287-9497
Colin R ParrishBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America.
Ian E H VoorheesBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, United States of America.ORCID 0000-0003-3189-1101
Yoshihiro KawaokaInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America.
Gabriele NeumannInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America.
Shiho ChibaInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America.
Shufang FanInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America.
Masato HattaInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America.
Huihui KongInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America.
Gongxun ZhongInfluenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison. Madison, Wisconsin, United States of America.
Guojun WangDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Melissa B UccelliniDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.ORCID 0000-0002-6551-1827
Daniel R PerezDepartment of Population Health, University of Georgia, Athens, Georgia, United States of America.ORCID 0000-0002-6569-5689
Lucas M FerreriDepartment of Population Health, University of Georgia, Athens, Georgia, United States of America.ORCID 0000-0002-1069-9500
Sander HerfstDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0001-9866-8903
Mathilde RichardDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.ORCID 0000-0003-0240-9312
Ron FouchierDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
David BurkeCenter for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-8830-3951
David PattinsonCenter for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-0001-8203
Derek J SmithCenter for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-2393-1890
Victoria MeliopoulosDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Pamela FreidenDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.ORCID 0000-0001-6167-180X
Brandi LivingstonDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Bridgett SharpDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Sean CherryDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Juan Carlos DibTropical Health Foundation, Santa Marta, Magdalena, Colombia.
Guohua YangDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Charles J RussellDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Subrata BarmanDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Richard J WebbyDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Scott KraussDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Angela DannerDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Karlie WoodardDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Malik PeirisSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Republic of China.ORCID 0000-0001-8217-5995
R A P M PereraSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Republic of China.
M C W ChanSchool of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Republic of China.ORCID 0000-0001-8174-8405
Elena A GovorkovaDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.ORCID 0000-0001-9067-5682
Bindumadhav M MaratheDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.ORCID 0000-0002-9929-7566
Philippe N Q PascuaDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.ORCID 0000-0001-6777-2994
Gavin SmithProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.ORCID 0000-0001-5031-468X
Yao-Tsun LiProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Paul G ThomasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
Stacey Schultz-CherryDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.ORCID 0000-0002-2021-727X
St. Jude Children's Research Hospital · USUniversity of Rochester · USJohns Hopkins University · USUniversity of Wisconsin–Madison · USUniversity of Georgia · USEmory University · USCornell University · USErasmus MC · NLIcahn School of Medicine at Mount Sinai · USUniversity of Cambridge · GBUniversity of Hong Kong · HKBeth Israel Deaconess Medical Center · USChang Gung Memorial Hospital · TWDuke-NUS Medical School · SGUniversity of Chicago · US
Funding
Toward a Universal Influenza Virus VaccineP01AI097092 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AHMED, RAFI · 2012 to 2022
$17.6MOverall Priority Score P41GM103694 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D · 2013 to 2018
$6.9MDevelopment of a High-Throughput Microfluidics-Enabled Functional Assay for Rapidly Identifying Neutralizing AntibodiesR01AI141607 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI DE FIGUEIREDO, PAUL, HAN, ARUM · 2019 to 2023
$3.4MDynamics of the protective vaccine-induced human influenza neuraminidase B cell responseR01AI145332 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KOBIE, JAMES J, MARTINEZ-SOBRIDO, LUIS · 2019 to 2022
$3.0MNIAID NIH HHS HHSN272201400004CNIAID NIH HHS HHSN272201400005CNIAID NIH HHS HHSN272201400006CNIAID NIH HHS HHSN272201400007CNIAID NIH HHS HHSN272201400008CNIAID NIH HHS P01 AI097092NIAID NIH HHS R01 AI141607NIAID NIH HHS R01 AI145332NIGMS NIH HHS P41 GM103694
Abstract
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned.
Indexed as
AnimalsCommunicable Diseases, EmergingDog DiseasesDogsFerretsGuinea PigsHumansInfluenza A virusInfluenza A Virus, H3N2 SubtypeInfluenza A Virus, H3N8 SubtypeInfluenza, HumanMice, Inbred BALB CMice, Inbred C57BLMice, Inbred DBAUnited StatesZoonoses
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